Daily Journal Digest — 2026-07-28¶
過去 24 小時新增：Transplant ID × 25、One Health × 11、Food Security × 12，共 48 篇。
⭐ 今日亮點¶
- Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies
把IFI診斷失敗轉成可稽核框架 - Management of invasive fungal infections in the ICU
整理ICU IFI診斷治療決策框架
🔬 深入評讀¶
Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies¶
J Fungi (Basel) | IF 4.7 | DOI | PMID 42506260 | @Rivas-P2026DiagnosticFailure
- 設計：這是敘述性綜述，聚焦 invasive fungal infections 診斷失敗的成因、臨床後果與緩解策略；摘要未載明系統檢索流程、納入期間或特定國家地區。
- 樣本：文章涵蓋重症病人、血液疾病病人、HSCT recipients 與新生兒等高風險族群，並討論 invasive candidiasis、aspergillosis、mucormycosis、cryptococcosis、endemic mycoses 及罕見／新興黴菌感染。
- 關鍵論點：核心論點是 IFI 診斷失敗並非單一檢驗不準，而是 delayed、incorrect、incomplete diagnosis 的動態過程，受 host factor、pathogen factor、diagnostic tool 與醫療系統互動影響。作者提出 AFSP-Dx，以 syndromic bundle、族群特異診斷演算法、48–72 小時再評估與可稽核指標，連結早期辨識、精準治療與合理 antifungal 使用。
- Limitation：這是敘述性綜述，未提供系統性搜尋、風險偏倚評估或 pooled effect，因此不能量化 AFSP-Dx 對死亡率、用藥天數或診斷延遲的效益。不同 IFI、宿主族群與醫院微生物量能高度異質，框架落地仍需前瞻性驗證與本地流程調整。
- Bottom line：對 transplant ID 與血液科病人，IFI 診斷應被當成 stewardship 核心流程，而不是等檢驗結果的被動事件。
Management of invasive fungal infections in the ICU¶
Expert Rev Anti Infect Ther | DOI | PMID 42505243
- 設計：這是敘述性綜述，整理 ICU 中 invasive fungal infections 的流行病學、風險因子、定義、診斷策略與治療管理；摘要未提供檢索期間、納入研究數或國家地區限制。
- 樣本：涵蓋加護病房病人，特別強調 invasive pulmonary aspergillosis、invasive candidiasis 與 mucormycosis，也納入免疫低下與非典型免疫低下重症族群。比較重點不是單一介入組，而是 host factor、影像、mycology 與 non-culture-based tools 的整合判讀。
- 關鍵論點：文章指出 ICU IFI 管理困難來自 histopathological confirmation 常不可行，因此臨床需採 probabilistic approach，結合宿主風險、臨床與影像表現、mycological evidence。作者強調 ICU 場景下診斷定義需調整，non-culture-based tools 有價值但限制明顯，治療上需早期風險分層、目標化檢驗與 timely antifungal therapy。
- Limitation：敘述性綜述無法提供單一策略的 pooled effect 或推薦強度，也未量化早期治療、分子診斷或 multidisciplinary care 對死亡率的獨立影響。ICU IFI 的宿主異質性、colonization 與 infection 區辨困難，會限制診斷演算法的外推性。
- Bottom line：ICU IFI 的臨床價值在於及早把風險分層、影像與微生物證據合併判讀，避免只靠單一 culture 或 biomarker 決策。
🔴 Transplant & Opportunistic Infections¶
Head-to-head evaluation of host blood biomarkers for point-of-care TB triage: diagnostic accuracy study¶
Authors: Komakech K et al. | Journal: J Clin Microbiol | Date: 2026 Jul 27
DOI: 10.1128/jcm.00046-26 | PMID: 42506936
TL;DR: 烏干達623名疑似TB成人中，CRP ≥10 mg/L敏感度91%、特異度78%，達WHO triage門檻；parallel testing敏感度可升至96%。
嘻嘻：CRP老工具又立功，便宜快篩也能很帥。
A comparative performance evaluation of the VIDAS cytomegalovirus (CMV) interferon-gamma release assay (IGRA) and T-SPOT CMV for measuring CMV-specific T-cell responses in allogeneic hematopoietic stem cell transplant recipients receiving letermovir prophylaxis¶
Authors: Solano de la Asunción C et al. | Journal: J Clin Microbiol | Date: 2026 Jul 27
DOI: 10.1128/jcm.00756-26 | PMID: 42506914
TL;DR: 85名allo-HCT接受letermovir者、107件檢體顯示VIDAS CMV IGRA與T-SPOT CMV一致性僅中等（kappa 0.47），且皆無法預測停藥後CMV DNAemia。
不嘻嘻：免疫監測看起來很潮，預測力卻很社恐。
Itaconate negatively regulates innate immunity during fungal pneumonia¶
Authors: Draper T et al. | Journal: mBio | Date: 2026 Jul 27
DOI: 10.1128/mbio.01491-26 | PMID: 42505091
TL;DR: Acod1缺失小鼠清除肺部A. fumigatus較佳，與type 17 response、IL-1β、PGE2及macrophage ROS增加相關；itaconate反而削弱抗黴菌能力。
嘻嘻：代謝路徑竟是破口，抗黴菌免疫有新靶點了。
Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus-coinfected and antiretroviral treated non-human primates¶
Authors: Chao MC et al. | Journal: mSystems | Date: 2026 Jul 27
DOI: 10.1128/msystems.00329-26 | PMID: 42505123
TL;DR: 20隻NHP、477個感染組織的WGS發現116個新生Mtb突變；SIV共感染提高突變頻率與bacterial outgrowth，ART組則較多oxidative damage相關突變。
不嘻嘻：免疫壓力下Mtb突變更忙，細菌也太會加班。
Oxygenation-Based Severity Stratification and a Proposed Clinical Diagnostic Workflow for Non-HIV Pneumocystis jirovecii Pneumonia: A Single-Center Observational Study¶
Authors: Chen J et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 22
DOI: 10.3390/jof12070541 | PMID: 42506302
TL;DR: 49名non-HIV PJP成人中，30.6%需ICU-level care、30日死亡率10.2%；PaO2/FiO2 <200 mmHg與ICU、插管、死亡較高相關。
不嘻嘻：non-HIV PJP一缺氧就很兇，真的不能慢慢看。
Clinical Outcomes of Micafungin and Anidulafungin in Candidozyma auris (Formerly Candida auris) Candidemia: A Propensity Score-Matched Retrospective Cohort Study¶
Authors: Arslan E et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 22
DOI: 10.3390/jof12070537 | PMID: 42506298
TL;DR: 154名C. auris candidemia經PSM後，micafungin與anidulafungin 30日死亡率同為41.8%，14日死亡、microbiological response、relapse皆無顯著差異。
不嘻嘻：echinocandin換來換去，死亡率還是很會做人。
Pneumocystis jirovecii DNA in Serum for the Diagnosis of Pneumocystis Pneumonia in Patients with Hematologic Malignancies-A Retrospective Case Control Study¶
Authors: Ström Turesson C et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 20
DOI: 10.3390/jof12070534 | PMID: 42506295
TL;DR: 血液惡性腫瘤患者41例下呼吸道P. jirovecii陽性與36名對照中，serum PCR診斷PCP敏感度52%、特異度89%，對照全陰性。
不嘻嘻：serum PCR很優雅，但敏感度有點太佛系。
Bridging the "Valley of Death" in Antifungal Therapy: Next-Generation Biomimetic and Exosome-Inspired Nanocarriers for Invasive Candidiasis¶
Authors: Yoğurtçu BM et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 19
DOI: 10.3390/jof12070530 | PMID: 42506291
TL;DR: 2015–2025文獻回顧指出，biomimetic與exosome-inspired nanocarriers可改善invasive candidiasis藥物穿透、抗biofilm並降低宿主毒性，但仍需製程標準化與長期安全評估。
嘻嘻：奈米載體聽起來科幻，至少有機會補上老藥短板。
In Vitro Anti-Aspergillus Activity and Antifungal Interactions of Monoclonal Antibodies 1D2 and 4E4¶
Authors: Lian X et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 16
DOI: 10.3390/jof12070523 | PMID: 42506284
TL;DR: mAb 1D2對4種Aspergillus與voriconazole、posaconazole、amphotericin B、caspofungin皆呈additive；4E4交互作用則具species與藥物差異。
嘻嘻：mAb幫抗黴菌藥助攻，這組合拳值得期待。
Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies¶
Authors: Rivas-Pinedo P et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 08
DOI: 10.3390/jof12070498 | PMID: 42506260
TL;DR: IFI diagnostic failure常來自採檢延遲、biomarker脫離臨床脈絡、鑑定不完整與團隊斷裂；AFSP-Dx強調syndromic bundle與48–72小時再評估。
不嘻嘻：IFI診斷最怕各做各的，病人先被流程耽誤。
Coccidioidal Peritonitis: Clinical Characteristics, Treatment and Outcomes¶
Authors: Shubeilat JL et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 03
DOI: 10.3390/jof12070489 | PMID: 42506251
TL;DR: 37例coccidioidal peritonitis中，36例接受抗黴菌治療且皆有clinical response；停藥11例中2例復發，無死亡歸因於感染。
嘻嘻：腹膜coccidioidomycosis少見但可救，難得讓人鬆口氣。
Emergence and Comparative Analysis of Candidozyma auris Versus Candida spp. Candidemia in a Romanian Tertiary Hospital: A 7-Year Study on Resistance, Mortality and Independent Prognostic Factors¶
Authors: Smadu SG et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 01
DOI: 10.3390/jof12070482 | PMID: 42506244
TL;DR: 羅馬尼亞7年61例candidemia中，24例為C. auris；azole resistance達95.8%，院內死亡率70.5%，血小板<100,000/μL獨立預測死亡（HR 2.34）。
不嘻嘻：C. auris到哪都帶高死亡率，真是醫院版惡夢。
Expression Profiling and Molecular Modeling Analysis of Cyp51C 14α-Demethylase Associated with Azole Resistance in Clinical Aspergillus flavus Isolates¶
Authors: Hadrich I et al. | Journal: J Fungi (Basel) | Date: 2026 Jun 25
DOI: 10.3390/jof12070466 | PMID: 42506228
TL;DR: 34株臨床A. flavus中，itraconazole與posaconazole抗藥率14.71%、8.82%；6株抗藥株中5株cyp51C上調，D254N與I285V偏見於抗藥株。
不嘻嘻：A. flavus也開始熟悉azole套路，真不客氣。
Non-Interventional, Retrospective, Multicenter Study on the Renal Safety of Liposomal Amphotericin B in Critically Ill Patients with Invasive Pulmonary Aspergillosis¶
Authors: Suberviola B et al. | Journal: J Fungi (Basel) | Date: 2026 Jun 23
DOI: 10.3390/jof12070458 | PMID: 42506220
TL;DR: 65名ICU IPA患者接受L-AmB後，35.39%出現renal failure，多為輕微可逆；合併腎衰者死亡率82.6%較無腎衰57.1%高。
不嘻嘻：amphotericin B還是那位強但傷腎的老朋友。
Shift in Candidemia Epidemiology and Emerging Fluconazole Resistance in Candida parapsilosis: A Post-Pandemic Cohort Study in a Colombian High-Complexity Teaching Hospital¶
Authors: Muñoz-Lombo JP et al. | Journal: J Fungi (Basel) | Date: 2026 Jun 23
DOI: 10.3390/jof12070457 | PMID: 42506219
TL;DR: 哥倫比亞2022–2023年109例candidemia以non-C. albicans為主，C. parapsilosis占22.0%且28.6% fluconazole-resistant；30日死亡率42.2%。
不嘻嘻：C. parapsilosis抗藥抬頭，ICU日常又更難了。
The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells and humanized mice¶
Authors: Turner RL et al. | Journal: J Virol | Date: 2026 Jul 27
DOI: 10.1128/jvi.00612-26 | PMID: 42505120
TL;DR: HCMV UL22A及Y65/Y69殘基是CD34+ hematopoietic progenitor cells與humanized mice中有效reactivation所需，RANTES neutralization無法補回缺陷。
嘻嘻：HCMV latency拼圖又多一塊，病毒真的很會藏。
Prevalence, risk factors, clinical characteristics and outcomes of tuberculosis-associated immune reconstitution inflammatory syndrome in a HIV and tuberculosis low-incidence setting¶
Authors: Sepulcri C et al. | Journal: Eur J Clin Microbiol Infect Dis | Date: 2026 Jul 27
DOI: 10.1007/s10096-026-05609-y | PMID: 42507275
TL;DR: 義大利低發生率環境21名HIV合併TB者中，5例出現TB-IRIS；disseminated TB與較短TB-treatment-to-ART間隔較常見，INSHI criteria會漏掉1例。
不嘻嘻：TB-IRIS連criteria都會漏，臨床直覺還得在線。
Early Risk Identification of Sepsis During Induction Chemotherapy in Newly Diagnosed AML: A Nomogram-Based Tool¶
Authors: Gu CY et al. | Journal: Cancer Med | Date: 2026 Aug
DOI: 10.1002/cam4.72138 | PMID: 42504842
TL;DR: 192名新診斷AML induction第3–5天nomogram以TP53 mutation、AST、CRP、PCT與urea預測sepsis，bootstrap-corrected AUC 0.892；sepsis組1與5年存活較差。
嘻嘻：AML sepsis能早點抓到，值班醫師會少冒冷汗。
Beyond Cure: A Scoping Review of Post-Tuberculosis Long-Term Health Outcomes¶
Authors: Menon S et al. | Journal: Trop Med Infect Dis | Date: 2026 Jul 20
DOI: 10.3390/tropicalmed11070203 | PMID: 42506774
TL;DR: 9篇systematic review顯示TB治癒後仍增加COPD、肺癌、肝損傷與聽力損失風險；HIV、低CD4、年齡較大、既有肝病是重要高風險因子。
不嘻嘻：TB治癒不是句點，後遺症帳單還會寄來。
A Preliminary Analysis of Sex-Based Differences in Immune Status, ART Adherence, and Opportunistic Infections Among HIV-Positive Patients in Rural Eastern Cape, South Africa¶
Authors: Ntshobane I et al. | Journal: Trop Med Infect Dis | Date: 2026 Jul 04
DOI: 10.3390/tropicalmed11070183 | PMID: 42506753
TL;DR: 南非東開普155名HIV患者中，女性CD4與ART adherence較佳；CD4 <200、viral load未壓制與adherence差皆獨立增加opportunistic infections風險。
不嘻嘻：adherence一掉，伺機性感染就準時上班。
Tuberculous brain abscess mimicking a neoplastic lesion in a patient with well-controlled human immunodeficiency virus infection: illustrative case¶
Authors: Valdivia DJ et al. | Journal: J Neurosurg Case Lessons | Date: 2026 Jul 27
DOI: 10.3171/CASE26178 | PMID: 42508059
TL;DR: 43歲HIV控制良好男性出現類腫瘤ring-enhancing temporal mass，切除後由histology、acid-fast stain與PCR證實M. tuberculosis brain abscess，術後無新神經缺損。
嘻嘻：HIV控制好也別太放心，病理仍能破案。
Exploring risk factors for attributable mortality from fusariosis in hematological malignancy patients¶
Authors: Schantz D et al. | Journal: Leuk Lymphoma | Date: 2026 Jul 27
DOI: 10.1080/10428194.2026.2701953 | PMID: 42507371
TL;DR: 血液惡性腫瘤proven invasive Fusarium感染中，30日attributable mortality唯一顯著風險為neutrophil未恢復；90與180日則lymphocyte未恢復也達顯著。
不嘻嘻：neutrophil不回來，Fusarium就很難談判。
From Pandemic Innovation to Platform Diversification: A Systematic Review of Clinical and Preclinical Development of Non-SARS-CoV-2 mRNA Vaccines¶
Authors: Hudu SA et al. | Journal: Diseases | Date: 2026 Jun 26
DOI: 10.3390/diseases14070230 | PMID: 42505558
TL;DR: 40項non-SARS-CoV-2 mRNA vaccine研究中，influenza與RSV phase III seroconversion >70%且安全性良好；HIV、CMV、rabies與癌症疫苗多仍早期。
嘻嘻：mRNA平台開始多線開花，疫苗界終於不只防疫回憶。
Management of invasive fungal infections in the ICU¶
Authors: Chean D et al. | Journal: Expert Rev Anti Infect Ther | Date: 2026 Jul 27
DOI: 10.1080/14787210.2026.2710718 | PMID: 42505243
TL;DR: ICU IFI管理需以host factor、影像、mycology與非culture檢測整合判斷；IPA、invasive candidiasis與mucormycosis死亡率高，早期風險分層與multidisciplinary care是核心。
不嘻嘻：ICU黴菌感染沒有單招，少一環就容易翻車。
New tuberculosis vaccines for people with HIV¶
Authors: Sumner T et al. | Journal: AIDS | Date: 2026 Jul 23
DOI: 10.1097/QAD.0000000000004583 | PMID: 42504585
TL;DR: 15個HIV/TB高負擔國家模型顯示，若TB vaccine對PWH同樣有效，2030–2050可避免19–25% PWH TB病例；僅間接效果則約5–13%。
嘻嘻：PWH若也吃得到疫苗紅利，TB防治會很有感。
🟢 One Health / Zoonoses¶
Accelerating Campylobacter zoonosis in the Anthropocene¶
Authors: Kyne OJ et al. | Journal: Proc Natl Acad Sci U S A | Date: 2026 Aug 11
DOI: 10.1073/pnas.2609969123 | PMID: 42507914
TL;DR: 2,747個雞與野鳥C. jejuni genomes顯示，1900年後雞到野鳥host transition約增100倍，且雞適應株常取得oxidative stress、motility與AMR相關基因。
不嘻嘻：雞場病原外溢到野鳥，One Health又被點名。
Viral entry defines the hepatitis E virus species barrier in murine hepatocytes¶
Authors: Frericks N et al. | Journal: Emerg Microbes Infect | Date: 2026 Dec
DOI: 10.1080/22221751.2026.2706321 | PMID: 42506980
TL;DR: 鼠類hepatocytes可在RNA transfection後支持HEV replication與virion產生，但天然感染受阻於entry階段，block位於attachment之後、replication之前。
嘻嘻：HEV物種屏障卡在entry，找藥靶瞬間清楚許多。
Porcine Airway Organoids Reveal Strain-Associated Replication and Epithelial Host Response Signatures of a Reassortant H1N1 Virus¶
Authors: Lee H et al. | Journal: Emerg Microbes Infect | Date: 2026 Jul 27
DOI: 10.1080/22221751.2026.2703395 | PMID: 42504738
TL;DR: porcine airway organoids中，reassortant SNU01/H1N1/2023較GC0503與CA04產生更高infectious progeny，並誘發接近CA04的antiviral與inflammatory transcriptional profile。
不嘻嘻：重組H1N1在organoid很活躍，豬流感仍不安分。
Human pulmonary infection by Brucella suis vaccine strain S2 revealed by genome sequencing in China¶
Authors: Li K et al. | Journal: Emerg Microbes Infect | Date: 2026 Jul 27
DOI: 10.1080/22221751.2026.2703398 | PMID: 42504691
TL;DR: 中國77歲女性肺部brucellosis分離株經phage lysis、qPCR與third-generation sequencing確認為B. suis vaccine strain S2，與疫苗株identity 99.9996%。
不嘻嘻：疫苗株跑去造成感染，這劇情真的很會尷尬。
Veterinary-specific breakpoints for ceftiofur applicable to canine Escherichia coli¶
Authors: Dang X et al. | Journal: J Clin Microbiol | Date: 2026 Jul 27
DOI: 10.1128/jcm.00299-26 | PMID: 42506934
TL;DR: 犬隻E. coli ceftiofur breakpoint建議UTI MIC ≤1、2、≥4 µg/mL分別為susceptible、intermediate、resistant；non-urine門檻則≤0.125、0.25、≥0.5 µg/mL。
嘻嘻：獸醫breakpoint補起來，抗生素判讀終於少點猜測。
Droplet digital PCR-based nucleic acid amplification test for improved molecular and clinical diagnosis of severe fever with thrombocytopenia syndrome patients¶
Authors: Baek Y et al. | Journal: J Clin Microbiol | Date: 2026 Jul 27
DOI: 10.1128/jcm.00367-26 | PMID: 42506926
TL;DR: 29名SFTS與29名scrub typhus對照中，RT-ddPCR偵測極限3.82 copies/μL，敏感度82.75%、特異度100%、accuracy 91.38%，優於RT-qPCR與RT-nested PCR。
嘻嘻：ddPCR抓SFTS更穩，急診鑑別多一把利器。
Community Drivers of Leishmania Infection, Transmission and Control in Baringo County, Kenya: Implications for Integrated One Health Intervention Strategies¶
Authors: Maingi HN et al. | Journal: Trop Med Infect Dis | Date: 2026 Jul 14
DOI: 10.3390/tropicalmed11070197 | PMID: 42506767
TL;DR: 肯亞Baringo South 135名居民KAP調查中，leishmaniasis awareness達94.8%，但對犬隻reservoir與預防措施仍有缺口；獸醫端也缺乏犬隻Leishmania診療認知。
不嘻嘻：大家聽過leishmaniasis，防治細節卻還在迷路。
Age-Stratified Heterogeneity of Brucellosis Awareness and Knowledge Among Hospital-Attending Adults in an Endemic Turkish Province: A Single-Center Cross-Sectional KAP Study¶
Authors: Dalmanoğlu E et al. | Journal: Trop Med Infect Dis | Date: 2026 Jul 06
DOI: 10.3390/tropicalmed11070185 | PMID: 42506755
TL;DR: 土耳其Balıkesir 397名成人中，brucellosis既有認知率58.7%，且隨年齡由51.8%升至74.5%；年長者對發燒與乳量下降辨識較低、較依賴人際資訊來源。
不嘻嘻：brucellosis衛教看年齡差很多，訊息還沒送到位。
Ethanolic Leaf Extract of Annona muricata Pauses Plasmodium knowlesi Schizogony and Reduces Binding of Infected Red Blood Cells to Endothelial Cells¶
Authors: Lim YJ et al. | Journal: Trop Med Infect Dis | Date: 2026 Jul 06
DOI: 10.3390/tropicalmed11070184 | PMID: 42506754
TL;DR: A. muricata葉乙醇萃取物對P. knowlesi blood-stage schizogony IC50為9.65 µg/mL，作用為parasitostatic，並降低infected RBC與endothelium結合。
嘻嘻：植物萃取物有抗瘧線索，但離藥物還有長路。
Cystic Echinococcosis in Agro-Pastoral Regions: A 10-Year Retrospective Study (2015-2024) and the Case for a One Health Approach¶
Authors: Bouragba M et al. | Journal: Trop Med Infect Dis | Date: 2026 Jun 28
DOI: 10.3390/tropicalmed11070180 | PMID: 42506750
TL;DR: 阿爾及利亞Djelfa 2015–2024年326例手術確診cystic echinococcosis，累積手術發生率2.04/100,000 person-years，農村居住73.62%、犬隻接觸94.17%。
不嘻嘻：犬隻、畜牧、手術病例串起來，老病仍很會循環。
Antimicrobial Resistance Profiles of Bacterial Pathogens Associated with Acute Diarrheal Disease: A Three-Year Retrospective Study in a Romanian Tertiary-Care Hospital¶
Authors: Borcan AM et al. | Journal: Antibiotics (Basel) | Date: 2026 Jun 23
DOI: 10.3390/antibiotics15070632 | PMID: 42505595
TL;DR: 羅馬尼亞3年腹瀉病原監測顯示，C. jejuni與C. coli ciprofloxacin resistance達81.65%、85.15%；Shigella spp.對ampicillin與SXT抗藥率78.57%、68.75%。
不嘻嘻：腹瀉病原抗藥性這麼高，經驗治療又更心累。
🟡 Food Security / Food Safety¶
Bridging analytical gaps in perchlorate monitoring: a comprehensive study of food contamination and exposure risk in Spain¶
Authors: Ponz-Perelló P et al. | Journal: Food Chem | Date: 2026 Jul 22
DOI: 10.1016/j.foodchem.2026.150523 | PMID: 42508118
TL;DR: 西班牙115件食品中perchlorate檢出率95.7%，4件超過EU上限；風險評估顯示嬰兒與幼兒Hazard Index超過1，暴露風險最高。
不嘻嘻：食品污染最怕嬰幼兒買單，風險管理不能裝沒事。
Behind Tolerance and the Cost of Coexistence: The Cd-Mn Interaction in Sunflower Triggers Translocation Reconfiguration, Impacting Productivity and Food Security¶
Authors: Pereira AAS et al. | Journal: J Agric Food Chem | Date: 2026 Jul 26
DOI: 10.1021/acs.jafc.5c14272 | PMID: 42503651
TL;DR: 向日葵Cd-Mn交互作用中，Cd存在降低Mn uptake，Mn則增加Cd uptake與向shoot轉移；高Mn降低種子乾重、conversion efficiency與油含量，Cd入籽帶來食安疑慮。
不嘻嘻：重金屬進到種子裡，農業壓力直接變食安壓力。
Microbiomic Insights into Differential Snow Mold Severity in Winter Cereal Crops¶
Authors: Sakhabutdinov IT et al. | Journal: J Fungi (Basel) | Date: 2026 Jul 07
DOI: 10.3390/jof12070496 | PMID: 42506258
TL;DR: 冬季穀物snow mold嚴重度差異不只由pathogen abundance解釋；健康與病株主要差異在candidate hub taxa與co-occurrence network，且呈作物特異性。
嘻嘻：作物微生物網絡比單一病原更有戲，防治可更精準。
Genome Re-Sequencing and Functional Analysis Reveal an α-1,3-Glucosyltransferase Conferring Metalaxyl Resistance in Phytophthora sojae¶
Authors: Gao J et al. | Journal: J Fungi (Basel) | Date: 2026 Jun 30
DOI: 10.3390/jof12070479 | PMID: 42506241
TL;DR: 6株metalaxyl-resistant P. sojae突變株resistance factor >2000；共同非同義突變指向PsALG8，CRISPR knockout顯著降低metalaxyl tolerance（p<0.01）。
嘻嘻：找到metalaxyl抗藥關鍵基因，植物病害也能拆機制。
Characterization of Bacillus stercoris JK-6 as an Antifungal Agent Against Crop Fungal Diseases¶
Authors: Ouyang Q et al. | Journal: J Fungi (Basel) | Date: 2026 Jun 25
DOI: 10.3390/jof12070467 | PMID: 42506229
TL;DR: B. stercoris JK-6 fermentation broth對M. oryzae、B. maydis、F. graminearum抑制率94.96%、75.83%、70.46%；200 μM surfactin具廣效抗黴菌活性。
嘻嘻：PGPR抗黴菌效果亮眼，田間替代方案有點希望。
Global Distribution and Comparative Resistance Profiles of Escherichia coli Isolated From Bovine Meat and Meat Products: Evidence From Network Meta-Analysis¶
Authors: Khorram Del Y et al. | Journal: Food Sci Nutr | Date: 2026 Jul
DOI: 10.1002/fsn3.72136 | PMID: 42504196
TL;DR: 100篇、41國、221,420株牛肉來源E. coli NMA顯示，penicillins與diaminopyrimidines抗藥最高；開發中國家抗藥率31.73%，近已開發國17.03%兩倍。
不嘻嘻：牛肉來源E. coli抗藥差距，全球化也很會分層。
An Indigenous Food Is Medicine Intervention: The MUTTON-HF Randomized Clinical Trial¶
Authors: Eberly LA et al. | Journal: JAMA Intern Med | Date: 2026 Jul 27
DOI: 10.1001/jamainternmed.2026.2879 | PMID: 42507456
TL;DR: MUTTON-HF納入206名Navajo Nation心衰竭患者，傳統食物medically tailored meals使90日住院或急診由57.0%降至40.6%（RR 0.72）。
嘻嘻：傳統食物能少住院，這才是貼近生活的醫療。
Plant growth-promoting rhizobacteria (PGPR) producing ACC deaminase and exopolysaccharides enhance salt tolerance in wheat¶
Authors: Hayat M et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Jul 27
DOI: 10.1007/s11274-026-05157-9 | PMID: 42507180
TL;DR: 8株ACCD或EPS-producing PGPR共接種可在150 mM NaCl下使小麥fresh biomass與根芽長約增30%，並上調rbcS、rbcL、cAPX、DREB2。
嘻嘻：讓小麥扛鹽壓，益生菌也能當農業隊友。
Phylogenetic Groups and Antibiotic Resistance Genes of Escherichia coli isolated from Food and Humans in Ouagadougou, Burkina Faso¶
Authors: Kpoda DS et al. | Journal: Curr Microbiol | Date: 2026 Jul 27
DOI: 10.1007/s00284-026-05066-y | PMID: 42507141
TL;DR: 布吉納法索144株E. coli中，臨床株cephalosporins與fluoroquinolones抗藥率最高達56%與57%；CTX-M與TEM主要見於phylogroup A。
不嘻嘻：CTX-M在食物與臨床間現身，抗藥鏈條很完整。
The Burden of Malnutrition and Confounders Among Children Aged Between 6 and 60 Months: A Community-Based Cross-Sectional Study in Resources Constraint Region¶
Authors: Tripathi P et al. | Journal: Matern Child Health J | Date: 2026 Jul 27
DOI: 10.1007/s10995-026-04300-0 | PMID: 42507069
TL;DR: 301名6–60個月兒童中，severe acute malnutrition、moderate malnutrition、acute malnutrition分別為8.97%、10.96%、18.93%；父母用tobacco與SAM odds增加相關（OR 6.508）。
不嘻嘻：兒童營養不良牽動家庭風險，公共衛生又在補洞。
Untargeted Metabolomics Reveals Distinct Metabolic Signatures of Lactic Acid Bacteria in Food Fermentation and the Same Pipeline Applied to Foodborne Pathogen Detection¶
Authors: Li H et al. | Journal: Metabolites | Date: 2026 Jul 22
DOI: 10.3390/metabo16070513 | PMID: 42506464
TL;DR: LAB fermentation untargeted metabolomics標註847個metabolites、312個顯著改變；同一流程用於食品病原偵測時，E. coli O157:H7、S. enterica、L. monocytogenes AUC為0.89、0.87、0.88。
嘻嘻：metabolomics從發酵走到病原偵測，平台感很強。
ESBL- and pAmpC-Producing Salmonella spp. and Escherichia coli O157:H7 Isolated from Bovine Carcasses in Türkiye¶
Authors: Koçak Kızanlık P et al. | Journal: Antibiotics (Basel) | Date: 2026 Jul 03
DOI: 10.3390/antibiotics15070658 | PMID: 42505621
TL;DR: 300具牛屠體分離25株Salmonella spp.與20株E. coli O157:H7；31株phenotypic ESBL-positive中29株帶ESBL基因，MDR比例75.6%。
不嘻嘻：屠體上的MDR腸道菌，餐桌前就先讓人皺眉。
資料來源：PubMed (articles retrieved 2026-07-28)