Daily Journal Digest — 2026-08-03¶

過去 24 小時新增：Transplant ID × 7、One Health × 10、Food Security × 10，共 27 篇。

⭐ 今日亮點¶

Augmenting immune reconstitution after adult allo-haematopoietic stem cell transplantation: current developments and modifiable determinants
allo-HSCT 感染風險框架更新

🔬 深入評讀¶

Augmenting immune reconstitution after adult allo-haematopoietic stem cell transplantation: current developments and modifiable determinants¶

Curr Opin Hematol | DOI | PMID 42542942

設計：這是成人 allo-HSCT 後 immune reconstitution 的敘述性綜述，聚焦 GvHD prophylaxis、serotherapy exposure、CMV control、functional immune monitoring 與 adoptive cellular therapy 等可調整因子。摘要未提供系統性檢索策略、研究期間或特定國家／地區範圍。
樣本：本文涵蓋成人 allo-HSCT 相關免疫重建文獻，重點包括 serotherapy dosing、CMV prophylaxis、virus-specific T-cells、thymic regeneration、cytokine-based strategies 與疫苗免疫原性資料。作為綜述，摘要未列出納入研究數、比較組或追蹤時間。
關鍵論點：核心論點是 immune reconstitution 不應只看 lymphocyte subset counts，而要走向 function- and exposure-guided assessment。作者指出 serotherapy exposure、GvHD prophylaxis、CMV control、microbiome preservation 與 selective adoptive immune replacement 已逐漸可支援個別化決策，但前瞻驗證的介入閾值仍少。
Limitation：主要限制是敘述性綜述本身未顯示系統性檢索、RoB 評估或證據分級，因此不同介入的證據強度不易橫向比較。許多策略仍停留在風險調整、免疫監測或 investigational 階段，尚不能直接轉成一致的 bedside algorithm。
Bottom line：成人 allo-HSCT 後感染預防正在從固定方案走向以 exposure、CMV 控制與功能性免疫監測驅動的個別化照護。

🔴 Transplant & Opportunistic Infections¶

Application of metagenomic next-generation sequencing as an adjunct to conventional microbiological testing for the diagnosis of infection in kidney transplant recipients¶

Authors: Vuth H et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1713707 | PMID: 42539859

TL;DR: 腎臟移植疑似感染 243 件檢體中，mNGS 陽性率 78.95–92.71%，遠高於 CMT；60.11% 個案依結果調整抗感染治療。

嘻嘻：移植感染終於有比較亮的手電筒了。

Augmenting immune reconstitution after adult allo-haematopoietic stem cell transplantation: current developments and modifiable determinants¶

Authors: Grocott SJ et al. | Journal: Curr Opin Hematol | Date: 2026 Jul 28
DOI: 10.1097/MOH.0000000000000944 | PMID: 42542942

TL;DR: 成人 allo-HSCT 後 immune reconstitution 已可透過 GvHD prophylaxis、serotherapy exposure、CMV 控制與 virus-specific T-cells 個別化調整。

嘻嘻：allo-HSCT 免疫重建開始像精準醫療了。

Severe Ulcerative Colitis With Cytomegalovirus Colitis Treated by Early Surgery: A Case Report¶

Authors: Fujimura H et al. | Journal: Clin Case Rep | Date: 2026 Aug
DOI: 10.1002/ccr3.73254 | PMID: 42542709

TL;DR: 急性重症 ulcerative colitis 合併 CMV colitis 時，若屬高風險且預期藥物治療效益有限，早期手術可作為個別化處置選項。

嘻嘻：早點請外科，有時比硬撐更像醫療。

The potential of bacteriocins in invasive fungal infections: Antifungal activities and intestinal protection¶

Authors: Wang J et al. | Journal: Microbiol Res | Date: 2026 Jul 30
DOI: 10.1016/j.micres.2026.128654 | PMID: 42541938

TL;DR: bacteriocins 具抗真菌活性，並可能保護腸道 microbial、mechanical、chemical 與 immune barriers，對 invasive candidiasis 與 Candida auris 有開發潛力。

嘻嘻：bacteriocins 也想加入抗真菌戰隊。

Incidence, risk factors, and outcomes of anti-tuberculosis drug-induced hepatotoxicity in people with and without HIV in Thailand and the Philippines¶

Authors: Atuel RCG et al. | Journal: Asian Biomed (Res Rev News) | Date: 2026 Jun
DOI: 10.2478/abm-2026-0020 | PMID: 42541216

TL;DR: 泰國與菲律賓 222 名 TB 患者中，DIH 發生率 PLWH 13.8%、HIV 陰性 9.5%；HCV coinfection 與低 BMI 為 PLWH 主要風險因子。

不嘻嘻：TB 藥還沒打完，肝先喊離職。

An Organoselenium Compound Induces Death in Cryptococcus gattii Yeast by Apoptosis and Necrosis and Shows Antifungal Efficacy in Galleria mellonella¶

Authors: da Costa LS et al. | Journal: ACS Omega | Date: 2026 Jul 28
DOI: 10.1021/acsomega.6c02274 | PMID: 42540316

TL;DR: organoselenium LQA_78 對 Cryptococcus gattii MIC 2–32 μg/mL，降低 melanin 與 laccase activity，並在 Galleria mellonella 降低死亡率與 fungal burden。

嘻嘻：C. gattii 面前多一個候補打手。

Multifocal Cutaneous and Musculoskeletal Mycobacterium haemophilum Infection Mimicking Erythema Nodosum and Crystal Arthropathy in a Kidney Transplant Recipient: A Case Report¶

Authors: Behrman Z et al. | Journal: Case Rep Transplant | Date: 2026
DOI: 10.1155/crit/9038193 | PMID: 42539693

TL;DR: 腎臟移植受者多發皮膚與肌肉骨骼 Mycobacterium haemophilum infection 可偽裝成 erythema nodosum 與 crystal arthropathy，PCR 協助診斷。

不嘻嘻：移植後的皮疹，永遠不只皮膚科的事。

🟢 One Health / Zoonoses¶

Parahenipavirus langyaense (Langya virus): Spillover ecology, noncanonical receptor-mediated entry, and future control strategies¶

Authors: Shen L et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101521 | PMID: 42541310

TL;DR: Langya virus 為中國東部新興 zoonotic paramyxovirus，宿主生態指向鼩鼱、囓齒類與農業介面；尚未證實持續人傳人。

不嘻嘻：新興 zoonosis 又在門口探頭了。

Making progress on One Health policies and programmes: Perspectives on community engagement and gender equity in four West African countries¶

Authors: Mayhew SH et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101511 | PMID: 42541099

TL;DR: 幾內亞、賴比瑞亞、奈及利亞、獅子山 One Health 政策多未操作化 gender equity；47 位利害關係人與 34 場 FGD 顯示信任與女性參與是關鍵缺口。

不嘻嘻：One Health 沒有信任，就只剩口號。

Molecular detection of Rickettsia species in ticks infesting synanthropic hedgehogs in Southeastern Iran¶

Authors: Tokasi M et al. | Journal: Vet Res Commun | Date: 2026 Aug 01
DOI: 10.1007/s11259-026-11433-8 | PMID: 42541635

TL;DR: 伊朗東南部 45 個刺蝟 tick pools 中 5 個（11.1%）檢出 Rickettsia spp. DNA，推定含 R. sibirica 與 R. rhipicephali。

不嘻嘻：tick 又默默幫 Rickettsia 跑外勤。

Molecular detection of Ehrlichia canis and Rickettsia rickettsii in tick-infested dogs from the city of Chihuahua, Mexico: phylogenetic analysis of the gp36 and ompA genes¶

Authors: Sánchez Pérez MJ et al. | Journal: Vet Res Commun | Date: 2026 Aug 01
DOI: 10.1007/s11259-026-11442-7 | PMID: 42541529

TL;DR: 墨西哥吉娃娃市 123 隻帶 tick 犬中，Ehrlichia canis 陽性 16.2%、Rickettsia rickettsii 3.2%，序列與美國株接近。

不嘻嘻：狗狗帶來愛，也可能帶來 tick 警訊。

D347G in PA is critical for the pathogenicity of H9N2 avian influenza A virus in mice¶

Authors: Zhao Z et al. | Journal: Virulence | Date: 2026 Dec
DOI: 10.1080/21505594.2026.2711518 | PMID: 42543038

TL;DR: H9N2 avian influenza A virus 分離株 JX198 對小鼠致死，PA D347G 突變提升 polymerase activity、vRNA production 與 plaque formation。

不嘻嘻：H9N2 只要一個 PA 突變就很會搞事。

Global translational reprogramming in Trichophyton mentagrophytes-infected keratinocytes¶

Authors: Wan J et al. | Journal: Virulence | Date: 2026 Dec 31
DOI: 10.1080/21505594.2026.2710548 | PMID: 42543036

TL;DR: Trichophyton mentagrophytes 感染 keratinocytes 後，RNA-seq 顯示 3,189 個 DEG、Ribo-seq 顯示 295 個 DTG，轉錄與轉譯重疊很少。

嘻嘻：dermatophyte 生物學又被拆得更細了。

Seasonal and Spatial Dynamics of Tick Infestation in Domestic Animals of Wayanad Forest Region, Southern India: A Longitudinal Survey¶

Authors: Viswanath MTS et al. | Journal: Environ Health Insights | Date: 2026
DOI: 10.1177/11786302261452465 | PMID: 42542768

TL;DR: 印度喀拉拉 Wayanad 2022–2024 年 2,562 隻 ticks 中，雨季最多 48.06%、牛隻負荷最高 59.7%；夏季 burden 較雨季低（IRR 0.36）。

不嘻嘻：雨季一來，tick 也開始加班打卡。

Improvements in knowledge and detection of carbapenemase-producing Enterobacterales transmission in companion animals will strengthen prevention across the One Health spectrum¶

Authors: Frey E et al. | Journal: Am J Vet Res | Date: 2026 Jul 31
DOI: 10.2460/ajvr.26.06.0273 | PMID: 42542133

TL;DR: companion animals 的 CP-CRE 雖少見但 veterinary hospital outbreaks 增加；盛行率、carriage dynamics、風險因子與 carbapenemase testing 仍缺乏標準化資料。

不嘻嘻：CP-CRE 也懂寵物醫院這條路。

Fish and fisheries in Bangladesh: Zoonotic risks, AMR, and environmental challenges under a one health perspective¶

Authors: Kayesh MKH et al. | Journal: Sci Total Environ | Date: 2026 Aug 01
DOI: 10.1016/j.scitotenv.2026.182097 | PMID: 42541944

TL;DR: 孟加拉漁業面臨 zoonotic parasites、Vibrio spp.、Aeromonas spp.、Mycobacterium spp.、AMR 與污染交會風險；87 篇資料支持 One Health 監測。

不嘻嘻：魚、環境、AMR 全部攪在同一鍋。

Prevalence, antimicrobial resistance and detection of resistance genes of Escherichia coli and Salmonella spp. isolated from captive European wild boars reared in Brazil¶

Authors: Faria AM et al. | Journal: Arch Microbiol | Date: 2026 Aug 01
DOI: 10.1007/s00203-026-05087-y | PMID: 42541606

TL;DR: 巴西圈養野豬 100 件直腸拭子中，Salmonella 1%、E. coli 56%；E. coli 分離株 98.2% 為 multidrug-resistant。

不嘻嘻：野豬的 E. coli 抗藥性也太有志氣。

🟡 Food Security / Food Safety¶

Imidazolium polymerized ionic liquid-based membranes for the early warning detection of aflatoxins in fermented foods¶

Authors: Sun Y et al. | Journal: Food Chem | Date: 2026 Jul 28
DOI: 10.1016/j.foodchem.2026.150590 | PMID: 42542079

TL;DR: imidazolium PIL membranes 可偵測發酵食品 aflatoxins 與 precursors，LOD 0.1–1.0 μg/kg、LOQ 0.2–2.0 μg/kg，回收率 77.1–116.7%。

嘻嘻：發酵食品毒素預警變得更像現場工具。

Peer review of the pesticide risk assessment of the active substance Trichoderma asperellumT34¶

Authors: Álvarez F et al. | Journal: EFSA J | Date: 2026 Jul
DOI: 10.2903/j.efsa.2026.10235 | PMID: 42540421

TL;DR: EFSA 完成 Trichoderma asperellum T34 作為 ornamentals 與多種蔬果 fungicide 的 pesticide risk assessment peer review，列出可用 end points 與資料缺口。

不嘻嘻：biopesticide 聽起來天然，資料缺口照樣天然。

Peer review of the pesticide risk assessment of the active substance 8-methyldecan-2-yl propanoate¶

Authors: Álvarez F et al. | Journal: EFSA J | Date: 2026 Jul
DOI: 10.2903/j.efsa.2026.10234 | PMID: 42540385

TL;DR: EFSA peer review 評估 8-methyldecan-2-yl propanoate 作為 maize 與 sweet corn insecticide pheromone 的代表用途，整理 regulatory end points 與缺漏資料。

不嘻嘻：pheromone pesticide 也逃不過法規作業簿。

The Direct and Moderating Effect of Food Insecurity on Obesity-A Cross-Sectional Study¶

Authors: Mete B et al. | Journal: Food Sci Nutr | Date: 2026 Aug
DOI: 10.1002/fsn3.72193 | PMID: 42540222

TL;DR: 859 人橫斷面研究中，obesity 在輕、中、重度 food insecurity 為 4.5%、12%、11.3%；重度 food insecurity obesity odds 增至 2.075 倍。

不嘻嘻：吃不安穩，身體代謝也跟著亂套。

Perceptions about protein supplements among adults in Saudi Arabia (knowledge and attitude, use, health beliefs, and safety concerns)¶

Authors: Alaoufi S et al. | Journal: PeerJ | Date: 2026
DOI: 10.7717/peerj.21545 | PMID: 42542879

TL;DR: 沙烏地阿拉伯 358 名成人中，35.5% 曾用 protein supplements，64.8% 不知道相關風險；使用者 11.8% 曾有副作用，78% 需要選購指引。

不嘻嘻：protein supplements 比健身房傳說還需要說明書。

Field-Calibrated Threshold-Distance Assessment of Lead Dispersion from Controlled Lead-Acid Battery Plate Combustion¶

Authors: Roky MS et al. | Journal: Environ Pollut | Date: 2026 Aug 01
DOI: 10.1016/j.envpol.2026.128853 | PMID: 42542283

TL;DR: 孟加拉 Kushtia 控制燃燒 lead-acid battery plates 後，PM2.5、Pb deposition 與 red amaranth Pb 累積呈距離梯度；50 m setback 僅為預防性建議。

不嘻嘻：燒電池省小錢，鉛污染收大帳。

Synergistic regulation of surface O/N active sites and local conjugation in N-doped carbonized polymer dots for smartphone-assisted dual-mode sensing of Hg2¶

Authors: Li T et al. | Journal: Talanta | Date: 2026 Jul 24
DOI: 10.1016/j.talanta.2026.130349 | PMID: 42541881

TL;DR: N-CPDs smartphone dual-mode sensing 可量測水產食品 Hg2，fluorescence 與 colorimetric LOD 為 40.91、38.97 nM，回收率 90.11–108.88%。

嘻嘻：手機也能幫水產 Hg2 把關，算有點帥。

Portable X-ray fluorescence evaluation of heavy metals in landfill soils of Bangladesh: spatial distribution, ecological, and health risk assessment¶

Authors: Alam SS et al. | Journal: Environ Geochem Health | Date: 2026 Aug 01
DOI: 10.1007/s10653-026-03364-9 | PMID: 42541677

TL;DR: 孟加拉 Chattogram landfill slope 土壤重金屬明顯升高，Cu、Pb、Zn Igeo >3；成人與兒童 non-carcinogenic HI >1，兒童風險較高。

不嘻嘻：landfill 土壤重金屬，兒童先中招最難笑。

Scoring pesticide-likeness of organic compounds via explainable one-class machine learning¶

Authors: Mei S | Journal: Mol Divers | Date: 2026 Aug 01
DOI: 10.1007/s11030-026-11686-0 | PMID: 42541668

TL;DR: OCSVM pesticide-likeness scoring 以 pesticide-only training data 避免負樣本偏差；5-fold cross validation outlier rate 4%，外部 38 種 biopesticides 辨識率 92%。

嘻嘻：pesticide-likeness 終於比較像可解釋工具。

Dietary mycotoxin toxicity in Caenorhabditis elegans model: Insights into neurotoxicological and neuroendocrine effects¶

Authors: Oladepo AJ et al. | Journal: Adv Neurotoxicol | Date: 2026
DOI: 10.1016/bs.ant.2026.02.007 | PMID: 42540589

TL;DR: C. elegans 模型顯示 AFB1、FB1、DON、ZEA 可誘發 oxidative stress、mitochondrial dysfunction、DNA damage 與 neurotoxicity，涉及 SKN-1/Nrf2、DAF-16/FOXO。

不嘻嘻：mycotoxin 的神經毒性戲份還真不少。

資料來源：PubMed (articles retrieved 2026-08-03)