Daily Journal Digest — 2026-08-17¶
過去 24 小時新增：Transplant ID × 3、One Health × 6、Food Security × 6，共 15 篇。
⭐ 今日亮點¶
- MERS-CoV in the Middle East and Africa: from surveillance gaps in humans and dromedary camels to One Health frameworks for spillover, prevention, research and response preparedness
MERS跨區One Health準備框架
🔬 深入評讀¶
MERS-CoV in the Middle East and Africa: from surveillance gaps in humans and dromedary camels to One Health frameworks for spillover, prevention, research and response preparedness¶
Int J Infect Dis | IF 3.1 | DOI | PMID 42603685
- 設計：這是敘述性綜述與框架文章，聚焦2012年後MERS-CoV在中東與非洲的動物流行病學、人類病例監測落差，以及跨區One Health整備。作者以中東、北非、東非、非洲之角與薩赫爾部分地區的dromedary camel暴露證據為核心，提出中東-非洲駱駝帶的整合治理架構。
- 樣本：文章涵蓋自沙烏地阿拉伯2012年確認MERS-CoV以來，全球逾2600例實驗室確認病例、27國通報，以及多地dromedary camel感染或暴露資料；這不是系統性回顧，未提供正式納入研究數或RoB評估。重點族群包括camel-exposed populations、嚴重急性呼吸道感染或非典型肺炎患者、醫療照護場域，以及大規模集會與旅遊相關風險族群。
- 關鍵論點：作者指出MERS-CoV是低發生率但高後果的zoonotic coronavirus威脅，通報CFR偏高但可能高估infection fatality，因輕症與無症狀感染偵測不足。核心論點是「Africa paradox」：非洲dromedary camel暴露證據廣泛，卻少見PCR確認的人類病例，因此需要上游camel-human interface監測與減少spillover、下游醫療端快速診斷與IPC防止院內放大的雙屏障策略。
- Limitation：主要限制是敘述性綜述未明示系統性檢索、納入標準與證據品質評估，對非洲人類病例稀少的解釋仍可能混雜於檢驗量能、就醫可近性、通報系統與臨床警覺度差異。其政策框架合理但尚未經前瞻性實作驗證，跨國資料共享、pathogen access and benefit sharing與治理資源也可能是落地瓶頸。
- Bottom line：MERS-CoV不只是阿拉伯半島的零星威脅；對感染科與臨床微生物而言，應把camel-human介面監測、SARI/非典型肺炎診斷路徑、genomic surveillance與醫療端IPC視為同一套跨區整備系統。
🔴 Transplant & Opportunistic Infections¶
Clinical Characteristics, Antifungal Therapy, and Outcomes of Candida auris Candidemia: A Two-Center Cohort Study¶
Authors: Binsuwaidan R et al. | Journal: Infect Drug Resist | Date: 2026
DOI: 10.2147/IDR.S593900 | PMID: 42604368
TL;DR: 利雅德兩院228例C. auris candidemia中，fluconazole resistance達77%，echinocandins susceptibility>90%；monotherapy clearance較快且復發較少，高SOFA score預示存活較差。
不嘻嘻：C. auris又在提醒我們，真菌也很會內卷。
Dose-response relationship of pre-ICU corticosteroids and influenza-associated pulmonary aspergillosis: a multicenter target trial emulation¶
Authors: Xu S et al. | Journal: Ann Intensive Care | Date: 2026
DOI: 10.1016/j.aicoj.2026.100132 | PMID: 42604214
TL;DR: 中國中部48間ICU、2763名重症influenza成人中，pre-ICU corticosteroids與IAPA風險上升相關（weighted HR 2.11, 95% CI 1.25–3.56），約40–50 mg dexamethasone-equivalent即需警覺。
不嘻嘻：steroid這刀還是雙面刃，砍完病毒又請來霉菌。
French intensive care physicians' practices for the management of high-risk patients with invasive candidiasis: results from the multicenter INSPIRE survey¶
Authors: Dupont H et al. | Journal: Ann Intensive Care | Date: 2026
DOI: 10.1016/j.aicoj.2026.100131 | PMID: 42604083
TL;DR: 法國75名ICU醫師完成283個高風險invasive candidiasis情境；echinocandins為88.2%首選，87.5%在mycological susceptibility確認後de-escalation至azoles，empirical treatment差異仍大。
嘻嘻：至少de-escalation有被放在心上，ICU也能精打細算。
🟢 One Health / Zoonoses¶
MERS-CoV in the Middle East and Africa: from surveillance gaps in humans and dromedary camels to One Health frameworks for spillover, prevention, research and response preparedness¶
Authors: Azhar EI et al. | Journal: Int J Infect Dis | Date: 2026 Aug 15
DOI: 10.1016/j.ijid.2026.109046 | PMID: 42603685
TL;DR: MERS-CoV自2012年起累計逾2600例、27國通報，非洲駱駝暴露證據廣泛卻少見PCR確認人類病例；作者主張中東–非洲One Health surveillance與醫療端IPC雙屏障。
不嘻嘻：駱駝那端線索滿地，人類這端卻像關了雷達。
Giardia duodenalis and Entamoeba spp.: Coprological and antibody-based approaches across farm animals in Egypt¶
Authors: Toaleb NI et al. | Journal: BMC Vet Res | Date: 2026 Aug 14
DOI: 10.1186/s12917-026-05801-4 | PMID: 42603794
TL;DR: 埃及2674件農場動物糞便中，microscopy檢出Giardia 23.4%、Entamoeba 17.1%；自製sandwich ELISA檢出率升至45.2%與30.1%，可強化常規surveillance。
嘻嘻：ELISA一上場，腸道原蟲立刻比較藏不住。
miR-325-3p targets GSDMD in macrophages to attenuate lung injury induced by Streptococcus equi subsp. zooepidemicus¶
Authors: Li Y et al. | Journal: Vet Immunol Immunopathol | Date: 2026 Aug 14
DOI: 10.1016/j.vetimm.2026.111188 | PMID: 42603548
TL;DR: miR-325-3p可直接target GSDMD；在Streptococcus equi subsp. zooepidemicus感染macrophages與小鼠中，降低IL-1β、IL-18、肺部bacterial loads並減輕lung injury。
嘻嘻：miRNA能壓住pyroptosis，肺部發炎總算有新劇本。
Prevalence, serotype diversity, and antibiotic resistance of non-typhoidal Salmonella in East African poultry: A systematic review and meta-analysis¶
Authors: Mebratie DY et al. | Journal: Poult Sci | Date: 2026 Aug 03
DOI: 10.1016/j.psj.2026.107555 | PMID: 42603403
TL;DR: 東非家禽13篇研究、422株陽性isolate的meta-analysis顯示non-typhoidal Salmonella pooled prevalence為6%（95% CI 4–8%），pooled antibiotic resistance達65%，oxytetracycline resistance 84%。
不嘻嘻：家禽版Salmonella抗藥性，餐桌前先嘆一口氣。
Epidemiological study of Toxocara canis infection in dogs in selected regions of Egypt¶
Authors: Gattan HS et al. | Journal: Front Vet Sci | Date: 2026
DOI: 10.3389/fvets.2026.1895478 | PMID: 42601940
TL;DR: 埃及4省409隻犬的anti-T. canis IgG seroprevalence為25.9%（106/409），開羅最高32.2%；高齡、戶外飼養、與貓共居、coprophagy、自製食物與不規則deworming為風險因子。
不嘻嘻：狗狗驅蟲不規律，人類公共衛生就一起補考。
Co-circulation of Crimean-Congo hemorrhagic fever virus and spotted fever group Rickettsia in cattle and ticks from cattle in Kosovo¶
Authors: Italiya J et al. | Journal: Front Vet Sci | Date: 2026
DOI: 10.3389/fvets.2026.1888406 | PMID: 42601893
TL;DR: 科索沃Malishevë牛隻與ticks檢測顯示，110隻Rhipicephalus annulatus中9隻有SFG Rickettsia，100頭牛中23頭有CCHFV antibodies，支持tick-borne pathogens共同流行。
不嘻嘻：tick-borne pathogens開同樂會，牛隻只是入場券。
🟡 Food Security / Food Safety¶
Advances in Cultivated Meat Technology for Sustainable Alternative Protein Production: A Review¶
Authors: Shafi Z et al. | Journal: Biotechnol Bioeng | Date: 2026 Aug 16
DOI: 10.1002/bit.70347 | PMID: 42604593
TL;DR: Cultivated meat已在新加坡、美國完成關鍵regulatory milestones，但大規模量產仍受animal-component-free media、bioreactor、edible scaffold與downstream processing成本與品質限制。
嘻嘻：培養肉離科幻更近了，只是錢包還沒準備好。
Prevalence and genetic characterization of Toxoplasma gondii in retail meats from fresh Markets in Songkhla Province, Thailand¶
Authors: Kaewmanee S et al. | Journal: Parasite Epidemiol Control | Date: 2026 Aug
DOI: 10.1016/j.parepi.2026.e00531 | PMID: 42603977
TL;DR: 泰國宋卡府30個市場304件肉品中，T. gondii prevalence為4.93%（15/304），雞肉最高10.19%、豬肉3.74%、牛肉皆陰性；phylogenetic analysis顯示genetic heterogeneity。
不嘻嘻：生鮮肉裡的T. gondii，再次提醒廚房不是無菌室。
Traditional Ethiopian fermented condiments: a systematic review of microbial dynamics, nutritional transformations, and future perspectives¶
Authors: Cherinet MT et al. | Journal: J Food Sci Technol | Date: 2026 Sep
DOI: 10.1007/s13197-026-06764-y | PMID: 42603915
TL;DR: 衣索比亞發酵調味品systematic review顯示，Lactiplantibacillus plantarum、Pediococcus pentosaceus與Weissella spp.主導發酵，pH多降至3.6–4.5並有pathogen suppression潛力。
嘻嘻：傳統發酵食物裡，微生物也能當食品安全隊友。
Bioaccumulation and exposure to potentially toxic elements (PTEs) in marine species commercialized for human consumption in the Southern Region of Rio de Janeiro (SE, Brazil)¶
Authors: Reis GA et al. | Journal: Mar Pollut Bull | Date: 2026 Aug 15
DOI: 10.1016/j.marpolbul.2026.120254 | PMID: 42603537
TL;DR: 巴西里約熱內盧Sepetiba Bay市售10種海鮮檢測36種元素，As、Cd、Cu、Pb、Ni、Se、Zn常共同變動；多物種肌肉total As超過或達regulatory reference value，需持續監測。
不嘻嘻：海鮮好吃沒錯，重金屬套餐就先不用加大。
Do extreme climate events affect population mobility? The moderating role of food security in prefecture-level China¶
Authors: Mai W et al. | Journal: J Environ Manage | Date: 2026 Aug 15
DOI: 10.1016/j.jenvman.2026.130725 | PMID: 42603491
TL;DR: 中國177個地級市2018–2023年panel data顯示，極端氣候事件顯著降低人口流動；較高food security可緩衝負向關聯，效果受城市規模、區域經濟與海拔調節。
不嘻嘻：氣候災害連搬家都卡住，民生韌性不是口號。
Wheat microbiome interactions under climate change: Mechanisms of abiotic stress tolerance and sustainable crop resilience¶
Authors: Verma V et al. | Journal: Plant Physiol Biochem | Date: 2026 Aug 06
DOI: 10.1016/j.plaphy.2026.111626 | PMID: 42603438
TL;DR: 小麥在乾旱、高溫、鹽分壓力下會重塑rhizosphere microbiome，特別招募Bacillus與Pseudomonas，透過ROS、phytohormone、nutrient acquisition與ACC deaminase等機制提升stress tolerance。
嘻嘻：小麥會找微生物隊友抗壓，植物其實很懂組隊。
資料來源：PubMed (articles retrieved 2026-08-17)