Skip to content

Daily Journal Digest — 2026-08-21

過去 24 小時新增:Transplant ID × 18、One Health × 10、Food Security × 13,共 41 篇。

⭐ 今日亮點


🔬 深入評讀

Application of bacteriophages in the prevention and control of bacterial infectious diseases in animals

Front Microbiol | DOI | PMID 42621610

  • 設計:這是 2026 年 8 月 5 日發表於 Frontiers in Microbiology 的 narrative review,主題是動物細菌感染中 bacteriophages 的預防與控制;全文整合 livestock、poultry、aquaculture 與 engineered phage 平台,涵蓋直接 lytic therapy、phage display vaccine vector、CRISPR-Cas phage 與 phage-derived peptides/antibodies。
  • 樣本:不是單一臨床試驗,作者引用的關鍵證據包括 laying hens APEC phage cocktail、自然感染乳牛 Staphylococcus aureus mastitis pilot RCT(治療組 16 頭、對照組 7 頭)、swine-associated MDR Salmonella phage cocktail 的 Galleria mellonella 72 小時模型,以及 murine intestinal colonization CRISPR-phage 模型。
  • 關鍵論點:效應量在部分前臨床與小型動物研究很大:APEC laying hens 死亡率由 20% 降至 0、發病率下降 30%,乳牛 mastitis bacteriological cure 為 81.3%(13/16)對 28.6%(2/7,p=0.026),MDR Salmonella larvae 72 小時存活率由 3% 升至 90%,CRISPR-phage 可使目標 E. coli 減少 3–4 log。這些數字支持 phage 在精準清除與低 microbiota 干擾上的潛力,但多數結果來自小型、前臨床或 pilot 研究,穩健性仍不足以直接外推到田間常規使用。
  • Limitation:主要限制是 narrative review 本身沒有系統性搜尋、風險偏差評估或 meta-analysis,且納入研究跨物種、病原、給藥途徑與 outcome,異質性極高。轉譯瓶頸包括 host range 狹窄、pharmacokinetics 與 delivery 不穩、免疫清除、phage resistance、endotoxin/host DNA 殘留、GMP batch consistency,以及 veterinary phage products 仍缺乏一致的國際監管框架。
  • Bottom line:Bacteriophages 在動物感染控制上最有價值的定位不是取代所有抗生素,而是作為經快速診斷配對的精準抗感染工具;目前可優先推進高負擔、局部給藥可行、病原明確的場景,例如 Staphylococcus aureus mastitis、APEC、Salmonella 與 aquaculture Vibrio

Voriconazole versus itraconazole for antifungal prophylaxis in patients with graft-versus-host disease: A prospective randomized trial

Int J Hematol | DOI | PMID 42618875

  • 設計:這是一項前瞻性 randomized phase II selection trial,比較 voriconazole 與 itraconazole 作為 allogeneic HCT 後 GVHD 病人的抗黴菌預防;摘要未提供研究期間與國家/地區。主要成功定義為第 60 天前存活、未發生 protocol-defined proven/probable IFI,且研究藥物使用至少 48 天。
  • 樣本:共 66 位病人隨機分派,voriconazole 與 itraconazole 各 33 位;族群為 grade II-IV acute GVHD 或需 systemic corticosteroids 的 chronic GVHD 病人。介入期間為 60 天,摘要未提供更長期追蹤資料。
  • 關鍵數字:Protocol-defined prophylaxis success 為 voriconazole 88% 對 itraconazole 94%,差異 -6.1 percentage points(95% CI -20.0 to 7.7),依預先設定規則選出 itraconazole。Voriconazole 組無 protocol-defined IFI,itraconazole 組有 1 例 probable 與 1 例 possible IFI;grade 3/4 adverse events 分別為 27% 與 21%。
  • Limitation:樣本數小且為 phase II selection trial,原文摘要明確指出未具備建立兩藥抗黴菌療效差異的 power。主要 outcome 是含存活、IFI 與服藥天數的 composite endpoint,且 IFI 在 2008 與 2020 consensus criteria 下 post hoc reclassification 結果不同,顯示診斷分類對結論有影響。
  • Bottom line:在需 systemic corticosteroids 的 GVHD 病人,voriconazole 與 itraconazole 皆顯示可行的短期預防表現,但這篇主要支持 feasibility,不能拿來宣稱 itraconazole 臨床療效優於 voriconazole。
  • GRADE 證據等級:Very low ⊕◯◯◯

The lymphocyte function of allogeneic peripheral blood stem cell grafts is associated with relapse and cytomegalovirus reactivation

Transfusion | DOI | PMID 42619477

  • 設計:這是 allogeneic HSCT 的觀察性研究,將 53 份 donor peripheral blood stem cell(PBSC)grafts 的體外 lymphocyte function assay、activation marker 與 cytokine production,連結到受贈者後續感染、GvHD、relapse 與 survival。摘要未提供研究期間、國家或地區。
  • 樣本:研究納入 53 份 PBSC grafts,對應接受 allogeneic HSCT 的受贈者;比較重點是 graft T cell 對 mitogen/superantigen stimulation 的反應,以及 CD8+ T cell blasts 上 PD-1 expression 是否高於中位數。摘要未提供追蹤時間與各臨床事件的絕對發生率。
  • 關鍵數字:較低 graft T cell response upon mitogen 或 superantigen stimulation 分別與 CMV reactivation 相關(p=0.013、p=0.0028),且在 multivariable analysis 後仍顯著。CD8+ T cell blasts PD-1 expression 高於中位數的 graft recipients 有較高 relapse incidence 與較低 overall survival(p=0.02),提示 graft 免疫功能可能不只是細胞數量,而是可量測的移植後風險訊號。
  • Limitation:主要限制是樣本數小、觀察性設計,CMV reactivation、relapse 與 survival 的估計容易受 conditioning regimen、donor/recipient CMV serostatus、GVHD prophylaxis、免疫抑制強度與 preemptive therapy 等 confounding 影響。摘要未說明 outcome adjudication、追蹤長度、缺失資料、模型變項數與效應量,因此目前較適合作為 hypothesis-generating biomarker study。
  • Bottom line:PBSC graft 的 T cell functional assay 可能協助辨識 HSCT 後 CMV reactivation 與 relapse 風險,但在改變臨床決策前需要較大、多中心且校正充分的驗證研究。
  • GRADE 證據等級:Very low ⊕◯◯◯

🔴 Transplant & Opportunistic Infections

RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation

Authors: Tsansizi LI et al. | Journal: Science | Date: 2026 Aug 20
DOI: 10.1126/science.aed9286 | PMID: 42623469

TL;DR: RAD51 透過穩定 NETs 分隔局部發炎;在小鼠肺部 Aspergillus fumigatus 感染中抑制 RAD51 會拆解 NETs、降低肺部 cytokines,卻增加循環 NET 成分並惡化 type 2 inflammation 與 asthma。

嘻嘻:NETs 原來也會隔離戰場,免疫學又多一層機關。


Golidocitinib as salvage therapy before allogeneic hematopoietic stem cell transplantation in refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

Authors: Li Y et al. | Journal: Haematologica | Date: 2026 Aug 20
DOI: 10.3324/haematol.2026.300987 | PMID: 42622108

TL;DR: refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis 在 allogeneic HSCT 前使用 golidocitinib 作 salvage therapy;此筆 PMID 無 abstract,療效與安全性數字需待全文確認。

嘻嘻:golidocitinib 若真能撐到移植,會是救命的橋。


Pharmacokinetics of abacavir and lamivudine in infants living with HIV with and without rifampicin co-treatment

Authors: Beca LSDAB et al. | Journal: J Antimicrob Chemother | Date: 2026 Aug 04
DOI: 10.1093/jac/dkag281 | PMID: 42623117

TL;DR: 18 名 HIV 嬰兒藥動學子研究中,rifampicin 對 abacavir/lamivudine 暴露影響極小;abacavir AUC0-24h 21.9 vs 21.0 h mg/L,lamivudine 12.6 vs 12.4,無需調整劑量。

嘻嘻:嬰兒 HIV 治療少一個劑量煩惱,臨床很實用。


Urine detection of Histoplasma antigens among symptomatic people living with HIV (PLWH) in Mato Grosso do Sul, Brazil: A comparative study of EIA and Lateral Flow Assay

Authors: da Silva DG et al. | Journal: Med Mycol | Date: 2026 Aug 20
DOI: 10.1093/mmy/myag088 | PMID: 42622357

TL;DR: 巴西南馬托格羅索 78 名疑似 disseminated histoplasmosis 的 symptomatic PLWH 中,尿液 Histoplasma antigen 陽性率 23.1%;陽性者死亡率 27.8%,EIA 與 LFA 一致率 93.6%。

不嘻嘻Histoplasma 還是很會躲,尿液快篩至少別讓它白躲。


TLR9 and CYP3A5 polymorphisms influence the risk of BK polyomavirus reactivation in Chinese kidney transplant recipients

Authors: He S et al. | Journal: Microb Pathog | Date: 2026 Aug 19
DOI: 10.1016/j.micpath.2026.108785 | PMID: 42617435

TL;DR: 133 名中國腎移植受者追蹤 12 個月,BKV DNAuria 累積發生率 49.6%、DNAemia 6.0%;CYP3A5 rs776746 AA/AG 與較高 DNAuria 相關,TLR9 rs352140 TT 為探索性風險訊號。

不嘻嘻:BKV 又來提醒我們,移植後監測永遠不能鬆。


The pleural tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control

Authors: Cronin S et al. | Journal: JCI Insight | Date: 2026 Aug 20
DOI: 10.1172/jci.insight.201268 | PMID: 42623146

TL;DR: HIV-1/TB 胸水 microenvironment 富集 genetically intact HIV-1,並由 TB 相關 lipids 抑制 CD8+ T cell activation,形成低 antiviral immune pressure niche,可能促進 replication-competent HIV-1 persistence。

不嘻嘻:TB 胸水根本幫 HIV 開了豪華潛伏包廂。


Tuberculosis prevention in low- and middle-income settings in the Asia-Pacific region, a qualitative scoping review

Authors: Jops P et al. | Journal: Glob Public Health | Date: 2026 Dec 31
DOI: 10.1080/17441692.2026.2716988 | PMID: 42622242

TL;DR: 2015–2025 年亞太低中收入地區 40 篇 qualitative TB prevention 研究多聚焦 secondary prevention 與 healthcare workers;主要障礙為 health system weaknesses、stigma、infection control policies 不清。

不嘻嘻:TB prevention 老問題一籮筐,答案還是卡在系統。


The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications

Authors: Shi J et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1918068 | PMID: 42621465

TL;DR: HIV 相關 ASCVD 的 residual risk 可能由 trained immunity 驅動;Nef、LPS/TLR4-NF-κB、CMV coinfection 與部分 ART 可重塑 monocytes/macrophages,促進 foam cell formation、血管發炎與 plaque progression。

不嘻嘻:HIV 控住了,血管發炎還在默默加班。


Urinary CXCL9 Across the Spectrum of Kidney Allograft Inflammation

Authors: Cortes Garcia E et al. | Journal: Kidney Int Rep | Date: 2026 Oct
DOI: 10.1016/j.ekir.2026.106702 | PMID: 42621113

TL;DR: 3181 組腎移植 biopsy-urine pairs 顯示 uCXCL9:Cr 隨 Banff 2022 發炎表型階梯上升;加入 uCXCL9 後 multiclass AUC 由 0.797 升至 0.831、外部驗證由 0.801 升至 0.821。

嘻嘻:尿液 biomarker 能少猜一點,移植醫師會想鼓掌。


Application and prognostic analysis of endoscopic sinus surgery combined with multidisciplinary team management in rhino-orbito-cerebral mucormycosis

Authors: Liu T et al. | Journal: Front Surg | Date: 2026
DOI: 10.3389/fsurg.2026.1854275 | PMID: 42620431

TL;DR: 22 名 ROCM 接受 ESS 合併 MDT 管理,6 個月 remission 54.5%、死亡率 45.5%;intracranial extension 是唯一獨立死亡風險因子,OR 28.5(95% CI 2.1–387.4)。

不嘻嘻:ROCM 一進顱內,外科和藥物都瞬間變困難模式。


Characterizing Tuberculosis Medication Side Effects Using Video Directly Observed Therapy Monitoring in Uganda: Opportunities for Digital Pharmacovigilance

Authors: Sekandi JN et al. | Journal: Res Sq | Date: 2026 Aug 06
DOI: 10.21203/rs.3.rs-10595035/v1 | PMID: 42620230

TL;DR: 烏干達坎帕拉 68 名 drug-susceptible TB 成人使用 VDOT 追蹤副作用,joint/body pain 84%、body weakness 79%、尿色變紅 68%;HIV、吸菸、年齡 >30 歲與較高 burden score 相關。

嘻嘻:VDOT 順手抓副作用,TB 照護終於比較即時。


Herpes Simplex Virus Serostatus and 1-Year Mortality Among Allogeneic Hematopoietic Cell Transplant Recipients

Authors: Fischer MD et al. | Journal: medRxiv | Date: 2026 Aug 02
DOI: 10.64898/2026.07.30.26359369 | PMID: 42620013

TL;DR: 4016 名成人首次 aHCT 受者 1 年死亡率 29.8%;HSV-1 seropositive 與較高 all-cause mortality 相關,aHR 1.20(95% CI 1.06–1.36),主要由 relapse-related mortality 驅動。

不嘻嘻:HSV-1 serostatus 又默默補刀,移植風險表更厚了。


Human cytomegalovirus UL2 is not required for lytic replication or viral latency and reactivation

Authors: Bryant A et al. | Journal: bioRxiv | Date: 2026 Jul 31
DOI: 10.64898/2026.07.30.741858 | PMID: 42619993

TL;DR: HCMV UL2 在 THP-1 monocytes 與 primary human HPCs 中,對 lytic replication、infection、latency establishment/persistence 與 reactivation 皆非必要,提示其功能可能偏向 immune response 或 co-factor regulation。

嘻嘻:HCMV UL2 被排除嫌疑,下一個靶點請上場。


Machine learning approaches for tuberculosis prevalence and risk factor association among high-risk groups in Kigali health facilities

Authors: Igihozo T et al. | Journal: Res Sq | Date: 2026 Jul 27
DOI: 10.21203/rs.3.rs-10453356/v1 | PMID: 42619975

TL;DR: 盧安達基加利 2254 筆高風險族群 EMR 經排除 indeterminate GeneXpert 後留 358 例;balanced random forest 表現最佳,AUC 0.86,重要特徵含病灶位置、年齡、BMI、HIV 與 diabetes。

嘻嘻:機器學習抓 TB 風險,至少比憑直覺可靠多了。


The lymphocyte function of allogeneic peripheral blood stem cell grafts is associated with relapse and cytomegalovirus reactivation

Authors: Söderström A et al. | Journal: Transfusion | Date: 2026 Aug 20
DOI: 10.1111/trf.70374 | PMID: 42619477

TL;DR: 53 份 allogeneic PBSC grafts 中,較低 graft T cell mitogen/superantigen response 與 CMV reactivation 相關(p=0.013、0.0028);CD8+ T cell blasts PD-1 高於中位數則 relapse 較多、overall survival 較差。

不嘻嘻:graft 免疫功能不只是數字,是復發與 CMV 的伏筆。


Voriconazole versus itraconazole for antifungal prophylaxis in patients with graft-versus-host disease: A prospective randomized trial

Authors: Hayashi Y et al. | Journal: Int J Hematol | Date: 2026 Aug 19
DOI: 10.1007/s12185-026-04252-9 | PMID: 42618875

TL;DR: 66名需 systemic corticosteroids 的 GVHD 患者隨機接受 voriconazole 或 itraconazole 60天;成功率88% vs 94%,grade 3/4 adverse events 27% vs 21%。

不嘻嘻:azoles 擂台賽打成這樣,臨床選擇焦慮又被加班。


Binding of voriconazole aptamers and modulation of binding by cyclodextrins

Authors: Kamel A et al. | Journal: Nanotechnology | Date: 2026 Aug 19
DOI: 10.1088/1361-6528/ae9bcb | PMID: 42617631

TL;DR: 新 voriconazole aptamer VO3 的 KD 為26 μM且選擇性高,在1 M NaCl或無 Mg2+ 仍保有結合活性;β-cyclodextrin 可競爭結合。

嘻嘻:aptamer 連鹽海都撐得住,藥物監測多一點想像空間。


Vanillin derivatives as antifungal agents against Aspergillus fumigatus: in vitro activity, in vivo efficacy, and mechanistic insights

Authors: Flores Maldonado OE et al. | Journal: Can J Microbiol | Date: 2026 Aug 19
DOI: 10.1139/cjm-2025-0295 | PMID: 42617182

TL;DR: vanillin derivatives 對 A. fumigatus MIC 為0.25–1 mM,o-vanillin活性最佳;可降低 adhesion、biofilm 與 ergosterol,並在 aspergillosis model 有療效。

嘻嘻:香草味打真菌,聽起來像甜點其實有點帥。


🟢 One Health / Zoonoses

mSphere of Influence: The age of antifungal resistance

Authors: van Rhijn N | Journal: mSphere | Date: 2026 Aug 20
DOI: 10.1128/msphere.00009-26 | PMID: 42622420

TL;DR: 環境變遷可改變 Coccidioides immitis 棲地,推動 Valley fever 風險與 fungal diseases 擴散;One Health 視角有助理解 antifungal resistance 形成。

不嘻嘻:氣候一變,黴菌版圖也跟著開外掛。


Nipah virus Malaysia and Bangladesh strain-induced pathogenesis in mice lacking type I interferon receptor signaling

Authors: Amurri L et al. | Journal: PLoS Negl Trop Dis | Date: 2026 Aug 20
DOI: 10.1371/journal.pntd.0013894 | PMID: 42623407

TL;DR: IFNAR KO mice 對 NiV-Mal 與 NiV-Ban 感染具感受性;腹腔接種造成 encephalitis、肺部症候群與多器官 dissemination,鼻內接種多為 subclinical。

不嘻嘻:Nipah virus 還在提醒我們,IFN 不是裝飾品。


Brucellosis in healthcare settings: research advances in nosocomial infection prevention and control

Authors: Du X et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1859809 | PMID: 42620572

TL;DR: 醫療與實驗室相關 brucellosis 仍常見於 biosafety 不足與 Brucella 誤判;防治需工程控制、行政政策、PPE與完整暴露後處置。

不嘻嘻Brucella 又示範一次:實驗室粗心會記仇。


Enterohemorrhagic Escherichia coli: A Persistent Foodborne Pathogen and Ongoing Public Health Challenge

Authors: Alsharif GS | Journal: Foodborne Pathog Dis | Date: 2026 Aug 19
DOI: 10.1177/15353141261479164 | PMID: 42619404

TL;DR: EHEC 仍透過牛肉、未殺菌乳品、蔬菜與水傳播;非 O157 serotypes(O26、O103、O111、O145、O45、O121)在多地占比增加。

不嘻嘻:EHEC 老派但穩,食安課本永遠翻不完。


The plastisphere paradox: microplastics as engines of antimicrobial resistance and hosts for polymer degraders

Authors: Katiyar P et al. | Journal: World J Microbiol Biotechnol | Date: 2026 Aug 20
DOI: 10.1007/s11274-026-05164-w | PMID: 42622944

TL;DR: plastisphere biofilms 可同時富集 ARGs、ARB 與降解功能基因;bioaugmentation 可能促進 HGT,應先做嚴格 biosafety assessment。

不嘻嘻:microplastics 連抗藥性都能揪團,真的很會。


Comprehensive Genomic Analysis of the pO157 Plasmid in Enterohemorrhagic Escherichia coli O157:H7 Reveals Non-synonymous Variation in Virulence Factors

Authors: Smith LY et al. | Journal: Curr Microbiol | Date: 2026 Aug 20
DOI: 10.1007/s00284-026-05126-3 | PMID: 42622701

TL;DR: 153個 EHEC O157:H7 pO157 plasmids 長88.2–98.1 kb、含84–102 CDS;60個 core genes 與主要 virulence genes 全數保留,結構高度 conserved。

不嘻嘻:EHEC O157:H7 的 virulence 家底穩到讓人心累。


Application of bacteriophages in the prevention and control of bacterial infectious diseases in animals

Authors: Li J et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1851321 | PMID: 42621610

TL;DR: bacteriophages 可作為動物感染替代抗生素平台,涵蓋 lytic therapy、phage display 與 CRISPR-Cas theranostics;證據多仍停留 preclinical。

嘻嘻:phage therapy 很有戲,但離正式上場還要練兵。


Multi-stage insecticide potentials of Myristica fragrans against the invasive Aedes albopictus, and putative binding mechanism of myristicin targeting the odorant-binding proteins (OBPs)

Authors: Hamid PH et al. | Journal: Curr Res Parasitol Vector Borne Dis | Date: 2026
DOI: 10.1016/j.crpvbd.2026.100424 | PMID: 42621404

TL;DR: Myristica fragrans essential oil 自0.001%完全抑制 Aedes albopictus 孵化;100 ppm以上30分鐘達100%幼蟲死亡,成蟲24小時 LC50 為0.270%。

嘻嘻:肉荳蔻變防蚊武器,廚房突然很有戰力。


Current advances in the development of Nipah virus vaccines

Authors: Zhang X et al. | Journal: Curr Res Microb Sci | Date: 2026
DOI: 10.1016/j.crmicr.2026.100648 | PMID: 42620721

TL;DR: NiV 致死率可達40%–80%,目前無核准 antiviral drugs、immunotherapies 或商用 vaccines;多種 vaccine platforms 仍處研發階段。

不嘻嘻:NiV vaccine 還在路上,病毒已經在門口等很久。


Epidemiological study and risk factors of internal parasite infections in wild boar (Sus scrofa) in Mazandaran Province, northern Iran

Authors: Abolhasani Drounkola M et al. | Journal: Parasite Epidemiol Control | Date: 2026 Aug
DOI: 10.1016/j.parepi.2026.e00529 | PMID: 42620638

TL;DR: 伊朗馬贊德蘭15隻野豬全數至少有一種寄生蟲,共檢出13種;Macracanthorhynchus hirudinaceus 86.6%、Metastrongylus apri 53.3%最常見。

不嘻嘻:野豬寄生蟲全餐,田野醫學真的不會無聊。


🟡 Food Security / Food Safety

A Risk-Based Framework for Ranking Microbiological Hazards and Identifying Mitigation Strategies for Dried Fruits, Vegetables, Herbs, and Spices Used in Ready-to-Eat Foods

Authors: den Besten HMW et al. | Journal: Compr Rev Food Sci Food Saf | Date: 2026 Sep
DOI: 10.1111/1541-4337.70567 | PMID: 42619406

TL;DR: 低水活性乾燥食材仍可讓 bacterial pathogens 長期存活;此 risk-based framework 納入 outbreak、prevalence、pathogen levels 與供應鏈資料以排序風險。

不嘻嘻:乾貨也不乾淨,食安雷點比香料櫃還滿。


Occurrence of Food Chemical Contaminants in Entomophagy: Implications for Food Safety and Future Risk Assessment-A Scoping Review

Authors: Esgalhado M et al. | Journal: Compr Rev Food Sci Food Saf | Date: 2026 Sep
DOI: 10.1111/1541-4337.70613 | PMID: 42618896

TL;DR: scoping review 納入25項 edible insects 污染研究;金屬濃度多偏低,但 PAHs 與 acrylamide 受飼養基質及加工條件影響,仍需 exposure-based 監測。

不嘻嘻:昆蟲食品很未來,但污染物也跟著一起登場。


Pathways linking household food insecurity to undernutrition among under 5 children in migrant populations along the Thailand-Myanmar border: A Structural Equation Modeling approach

Authors: Than SM et al. | Journal: PLOS Glob Public Health | Date: 2026
DOI: 10.1371/journal.pgph.0006516 | PMID: 42623347

TL;DR: 泰緬邊境384名移工兒童中,營養不良37.0%、家庭food insecurity 63.8%;較高SES改善HAZ/WAZ,發燒與腹瀉則降低WHZ。

不嘻嘻:小孩肚子空空,SEM再漂亮也救不了晚餐。


Deep dive into the food potential of Salicornia bigelovii by comparing its nutritional value between its growth stages and with freshwater-based crops

Authors: Lyra DA et al. | Journal: J Sci Food Agric | Date: 2026 Aug 20
DOI: 10.1002/jsfa.70977 | PMID: 42622090

TL;DR: 11個Salicornia bigelovii genotypes顯示營養組成隨生長期改變;早期富含vitamin C/D與essential amino acids,晚期fiber、protein與minerals較高。

嘻嘻:鹽地植物也能當營養潛力股,餐桌未來有點鹹香。


Research Advances in Modern Immunoassay Technologies and Novel Alternative Biotechnologies for Rapid Detection of Foodborne Pathogens and Chemical Contaminants

Authors: Xiao J et al. | Journal: J Food Prot | Date: 2026 Aug 19
DOI: 10.1016/j.jfp.2026.100896 | PMID: 42617808

TL;DR: 食品安全rapid detection正由傳統colloidal gold轉向IF-QCT、FCI、aptamers、CRISPR/Cas與phage-based technologies,以補足微量偵測與定量限制。

嘻嘻:食安檢測工具箱越來越滿,實驗室終於有新玩具。


Coexistence and combined toxic effects of principal emerging and common mycotoxins

Authors: Jin Q et al. | Journal: Mycotoxin Res | Date: 2026 Aug 20
DOI: 10.1007/s12550-026-00670-0 | PMID: 42622876

TL;DR: emerging mycotoxins如BEA、ENNs、MON常與AFT、ZEN、OTA、DON共存,可能產生synergistic、additive或antagonistic toxicity,應納入混合暴露風險評估。

不嘻嘻:黴菌毒素還會組隊出擊,食安人生真是副本連開。


Resolution of MALDI-TOF MS compared to whole genome sequencing for the identification of Vibrio parahaemolyticus strains isolated from oysters

Authors: King T et al. | Journal: Arch Microbiol | Date: 2026 Aug 20
DOI: 10.1007/s00203-026-05142-8 | PMID: 42622867

TL;DR: 美國牡蠣分離70株Vibrio parahaemolyticus;MALDI-TOF MS mass spectra可呈現與WGS相近的來源cluster,種內cosine similarity 0.61–0.91、ANI 98–100%。

嘻嘻:MALDI-TOF MS若能多看一層,通報速度就有戲。


Occurrence and Characterization of Microplastics in the Gastrointestinal Tracts of Fish and a Crustacean from the Keralam Coast, Southeastern Arabian Sea

Authors: Soumya K et al. | Journal: Bull Environ Contam Toxicol | Date: 2026 Aug 20
DOI: 10.1007/s00128-026-04317-9 | PMID: 42622851

TL;DR: 印度喀拉拉海岸540件魚蝦樣本中,44.25%胃腸道含microplastics,雨季後最高55.56%;常見300–500 µm碎片,以polyethylene、polyurethane、polypropylene為主。

不嘻嘻:吃海鮮順便吃塑膠,這份加料真的不需要。


Uncertainties in global hydrological and climate models challenge future estimates of crop water use and sustainability

Authors: Sun Q et al. | Journal: Commun Earth Environ | Date: 2026
DOI: 10.1038/s43247-026-03621-w | PMID: 42620840

TL;DR: 多model推估顯示,本世紀末green與blue water footprints不確定性約18%與51%;blue water sustainability變異可達250–451%,hydrological model差異影響最大。

不嘻嘻:連作物用水都算不準,永續規劃先深呼吸。


Trust dynamics in social media crises: a topic-aspect-sentiment analysis of public evaluations during a school food safety incident

Authors: Bai Y et al. | Journal: Front Psychol | Date: 2026
DOI: 10.3389/fpsyg.2026.1895872 | PMID: 42620752

TL;DR: 雲南校園食安事件11,016則微博貼文顯示,負面評價集中於回應不足、責任歸屬與accountability fairness;補救期對監管介入較正向但整體仍偏負面。

不嘻嘻:食安危機最怕的不只出包,還有回應像慢動作。


Orally delivered chitosan-based Salmonella subunit nanovaccine provides protective immunity against colonization by Salmonella Enteritidis in adult layer chickens

Authors: Suresh R et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1879692 | PMID: 42620634

TL;DR: 蛋雞口服mChitosan(OMP+Fla)/Fla-NP nanovaccine後,以200 µg劑量在challenge後第4天使盲腸S. Enteritidis下降2.7 log,生殖道直接培養未檢出。

嘻嘻:口服疫苗能幫雞少帶菌,蛋桌安全感加一點。


Bactericidal and cell membrane disruption potential of protein extract from buttermilk-derived probiotic Pediococcus pentosaceus OBK05 against Salmonella typhimurium ATCC 14028

Authors: Boda P et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1869302 | PMID: 42620597

TL;DR: Pediococcus pentosaceus OBK05蛋白萃取物對Salmonella typhimurium ATCC 14028呈劑量依賴抑菌與快速bactericidal effect,機轉包含cell membrane disruption。

嘻嘻:益生菌蛋白也能拆膜殺菌,乳品副產物突然很會。


MOF-assisted colorimetric-photothermal dual-readout lateral flow assay for rapid detection of Salmonella typhimurium

Authors: Luo L et al. | Journal: Anal Chim Acta | Date: 2026 Oct 15
DOI: 10.1016/j.aca.2026.345981 | PMID: 42618132

TL;DR: ZIF-67@AuNPs phage-assisted LFIA偵測Salmonella typhimurium,photothermal conversion efficiency 45.7%;photothermal LOD達0.997×10^3 CFU/mL,敏感度約提升30倍。

嘻嘻:phage加photothermal讀值,Salmonella快篩變得很有科技感。


資料來源:PubMed (articles retrieved 2026-08-21)