Daily Journal Digest — 2026-09-04¶
過去 24 小時新增：Transplant ID × 16、One Health × 10、Food Security × 14，共 40 篇。
⭐ 今日亮點¶
- Rates of azole resistance in aspergillosis: a worldwide overview
AMR 與 One Health 交會的真菌警訊 - Interferon crosstalk at the lung barrier in viral and fungal infection
解釋 viral-fungal coinfection 的免疫框架 - Fungal diseases in burn and blast-injured patients: tensions are rising, and awareness must keep pace
戰傷與燒傷 IFD 診治框架更新
🔬 深入評讀¶
Rates of azole resistance in aspergillosis: a worldwide overview¶
Curr Opin Infect Dis | DOI | PMID 42687366
- 設計：這是敘述性綜述，整理全球 triazole-resistant Aspergillus fumigatus 的臨床與環境流行病學，以及抗藥性可能來源與 resistance mechanisms。文章重點放在 worldwide overview，而非單一國家或單一監測資料庫。
- 樣本：綜述涵蓋臨床與環境分離株研究，並指出歐洲資料最完整，其他洲也已出現環境與臨床 hotspots。原文未提供系統性納入研究數、統一研究期間或 pooled prevalence。
- 關鍵論點：核心訊息是 triazole-resistant A. fumigatus 已在所有可居住洲被偵測到，且常見 resistance mechanisms 指向環境／農業 azole 暴露。這使 azole resistance 不只是臨床用藥選擇問題，也是 One Health 與農業抗真菌壓力的跨域問題。
- Limitation：主要限制是現有 prevalence 受小型、短期研究與缺乏完整 surveillance programs 影響，全球真實負擔仍不清楚。由於不是系統性回顧，研究選取與證據權重也可能有敘述性偏差。
- Bottom line：遇到 invasive aspergillosis 時，azole resistance 應被視為臨床、環境與農業交織的 AMR 問題，而不是少數地區的例外。
Interferon crosstalk at the lung barrier in viral and fungal infection¶
Infect Immun | IF 3.0 | DOI | PMID 42684861
- 設計：這是 minireview，聚焦 lung barrier 中 type I、II、III IFNs 在 respiratory viral infection 與 pulmonary Aspergillus fumigatus infection 的交互作用。文章以機轉整合為主，涵蓋 epithelial sensing、myeloid antifungal sensing、JAK-STAT 訊號與 inflammatory pathway 整合。
- 樣本：此文不是原始世代或系統性回顧，未設定固定樣本數、追蹤時間或比較組。涵蓋的關鍵情境包括 influenza-associated pulmonary aspergillosis 與 COVID-19-associated pulmonary aspergillosis。
- 關鍵論點：主要論點是 IFN 效應高度依賴 class、ligand、cellular source、target、timing 與 duration；適時且空間受限的 IFN response 可促進 pathogen control 與 barrier preservation。相反地，過度、持續或錯時訊號可能妨礙 epithelial recovery、干擾 phagocyte activity，並增加 secondary fungal invasion susceptibility。
- Limitation：限制在於多數推論來自機轉與跨模型整合，不能直接轉成臨床介入門檻或治療時機。不同 viral-fungal coinfection 情境、宿主免疫狀態與治療暴露可能異質性很高。
- Bottom line：這篇提供理解 viral infection 後 aspergillosis 的免疫框架，臨床上提醒 IFN modulation 不能脫離時間點與細胞型別脈絡。
Fungal diseases in burn and blast-injured patients: tensions are rising, and awareness must keep pace¶
Curr Opin Infect Dis | DOI | PMID 42687404
- 設計：這是敘述性綜述，整理 burn 與 blast-injured patients 發生 invasive fungal diseases 的 susceptibility、診斷與治療策略。文章強調 burn-induced immunosuppression、分子診斷與 source control 的整合。
- 樣本：此文未提供系統性納入研究數或 pooled estimates，而是彙整近期文獻主題。目標族群是 severe burn injury 與 blast injury 後的高風險病人，尤其是生理變化會影響 antifungal pharmacokinetics 的族群。
- 關鍵論點：作者歸納近期文獻收斂於三個方向：辨識 burn-induced immunosuppression、將 conventional diagnostics 與 quantitative PCR 等 molecular tools 併用、以及 source control 加上 systemic antifungal therapy。治療上特別強調需依嚴重燒傷造成的生理改變做 pharmacokinetic optimization。
- Limitation：主要限制是診斷、預防與治療證據仍薄弱，缺乏共識 case definitions 與 prospective multicentre data。燒傷與戰傷病人高度異質，感染診斷也容易受傷口污染、組織壞死與採檢限制影響。
- Bottom line：燒傷與 blast injury 後 IFD 應以早期風險辨識、診斷組合、積極 source control 與個別化 antifungal dosing 共同處理。
🔴 Transplant & Opportunistic Infections¶
Retrospective comparison of mesenchymal stromal cells and antithymocyte globulin as second-line therapy for acute graft-versus-host disease¶
Authors: Murata M et al. | Journal: Cytotherapy | Date: 2026 Jun 11
DOI: 10.1016/j.jcyt.2026.102932 | PMID: 42685638
TL;DR: 日本registry 1120例steroid-refractory acute GVHD二線治療，MSC day 28 ORR高於ATG（62.7% vs 51.0%；OR 1.56），且100天invasive fungal/viral infection較少。
嘻嘻：GVHD二線終於看到比較順眼的感染結局。
Evidence-based standardization of infectious disease biobanking: aligning specimen preservation and clinical metadata with in vitro diagnostic clinical trials requirements¶
Authors: Xia C et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1903960 | PMID: 42688453
TL;DR: 中國單中心140項infectious disease IVD trials顯示serum/plasma佔75.7%，多數偏好frozen；-70°C長期保存、避免freeze-thaw與完整metadata是核心缺口。
嘻嘻：biobank標準化很無聊，但診斷試驗真的需要它。
Prevalence and associated factors of tuberculosis/HIV coinfection among people living with HIV in Almaty, Kazakhstan: a cross-sectional study¶
Authors: Denebayeva AY et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1816007 | PMID: 42688096
TL;DR: 阿拉木圖188名PLHIV中TB/HIV coinfection盛行率17%；detectable viral load關聯最強（aPR 6.9），smoking、TB接觸、incarceration與年輕年齡亦增加風險。
不嘻嘻：viral load沒壓住，TB就很會找門縫鑽。
Interferon crosstalk at the lung barrier in viral and fungal infection¶
Authors: Velez-Brochero M et al. | Journal: Infect Immun | Date: 2026 Sep 01
DOI: 10.1128/iai.00295-26 | PMID: 42684861
TL;DR: 肺部viral infection與pulmonary Aspergillus fumigatus infection中，IFN效應取決於class、來源、target與時間；過度或錯時訊號會妨礙epithelial repair並促進secondary fungal invasion。
不嘻嘻：IFN不是越多越好，肺會用發炎提醒你。
Epidemiology and Species Distribution of Candida Bloodstream Infections in a Comprehensive Cancer Center, 2008-2023¶
Authors: El-Atoum M et al. | Journal: Mycopathologia | Date: 2026 Sep 02
DOI: 10.1007/s11046-026-01088-z | PMID: 42684546
TL;DR: 癌症中心2008–2023年265 episodes candidemia發生率0.46/1000 patient-days；uncommon Candida species佔8.3%，血液惡性腫瘤達16.7%，neutropenia為獨立預測因子（OR 4.5）。
不嘻嘻：Candida冷門親戚在癌症病房也不想缺席。
Discovery of Novel Ligands for the Treatment of Cryptococcus neoformans Infection¶
Authors: Rocha T et al. | Journal: Arch Pharm (Weinheim) | Date: 2026 Sep
DOI: 10.1002/ardp.70324 | PMID: 42690198
TL;DR: 3-hydroxypyridin-4(1H)-one hybrids 5c–f對C. neoformans var. grubii具選擇性抗真菌活性，MIC 32 µg/mL，且HEK293/HepG2與hemolysis測試至25 μM未見明顯毒性。
嘻嘻：C. neoformans新藥苗頭，先給一點掌聲。
Divergent Practice Patterns in Lupus Nephritis Care: A National Survey of Rheumatologists and Nephrologists in Saudi Arabia¶
Authors: Alrowaie FA et al. | Journal: Saudi J Kidney Dis Transpl | Date: 2026 Sep 01
DOI: 10.4103/sjkdt.sjkdt_113_26 | PMID: 42690102
TL;DR: 沙烏地阿拉伯158名clinicians調查顯示lupus nephritis照護差異明顯：rheumatologists較常用MMF與高劑量methylprednisolone，nephrologists較常用cyclophosphamide與PJP prophylaxis。
不嘻嘻：lupus nephritis照護差異大，PJP只好自己緊張。
Tuberculosis Among Men Who Have Sex With Men Living With HIV in Israel: A Retrospective Nationwide Cohort Study, 2000-2025¶
Authors: Mor Z et al. | Journal: J Int Assoc Provid AIDS Care | Date: 2026
DOI: 10.1177/23259582261478436 | PMID: 42689389
TL;DR: 以色列2000–2025年3018名MSM LWHIV追蹤30617 person-years，tuberculosis僅16例（0.5%；5/10000 person-years），遠低於non-MSM LWHIV，多與endemic countries暴露相關。
嘻嘻：MSM LWHIV的TB風險低，這次流病有好消息。
Managing the Loss of Right Renal Venous Tissue in Deceased-Donor Organ Procurement¶
Authors: Emmanuel NMR et al. | Journal: J Transplant | Date: 2026
DOI: 10.1155/joot/3588832 | PMID: 42689177
TL;DR: 2018–2025年334個deceased-donor右腎中17例RCVC injury；15例以York Plastic reconstruction後成功移植，無renal vein thrombosis或stenosis，12個月14名存活者中13例graft functioning。
嘻嘻：腎靜脈修補救回移植，外科手感很可以。
Distinct Clinical and Prognostic Features of Acute and Chronic Active Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults: A Scoping Review¶
Authors: Gao T et al. | Journal: Immunotargets Ther | Date: 2026
DOI: 10.2147/ITT.S621828 | PMID: 42688930
TL;DR: 168篇文獻共714名成人EBV-HLH顯示AEBV-HLH較fulminant，中位OS 2.4個月，CAEBV-HLH為8.9個月；HSCT在兩亞型皆與較佳長期預後相關。
不嘻嘻：EBV-HLH還是狠角色，HSCT像最後救生圈。
Delayed Diagnosis of Rhino-Orbito-Facial Mucormycosis in a Patient With Newly Diagnosed Diabetes and Diabetic Ketoacidosis: A Successful Case From a Resource-Limited Setting¶
Authors: Riesehaymanot FT et al. | Journal: Case Rep Infect Dis | Date: 2026
DOI: 10.1155/crdi/3763579 | PMID: 42688847
TL;DR: 38歲新診斷diabetes合併mild DKA女性rhino-orbito-facial mucormycosis延遲診斷；反覆debridement、conventional amphotericin B與控糖後完全恢復，3年追蹤無復發。
嘻嘻：mucormycosis延誤還能翻盤，這例很硬。
Infection risk associated with talquetamab in relapsed/refractory multiple myeloma: a systematic review with meta-analysis of talquetamab monotherapy and descriptive analysis of combination therapy¶
Authors: Huang ZY et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1848518 | PMID: 42688493
TL;DR: 6項RRMM研究中，talquetamab monotherapy pooled any-grade infection為51%，grade ≥3 infection為22%，infection-related mortality 0–3.2%；常見SARS-CoV-2、CMV、bacterial pneumonia與PJP。
不嘻嘻：talquetamab很能打，感染帳單也跟著寄來。
Pulmonary rehabilitation in post-tuberculosis lung disease: a systematic review¶
Authors: Kumar K et al. | Journal: Front Med (Lausanne) | Date: 2026
DOI: 10.3389/fmed.2026.1929171 | PMID: 42688365
TL;DR: 17項post-tuberculosis lung disease研究顯示pulmonary rehabilitation可提升6MWD約36–189 m，SGRQ最多降13分，dyspnea與chest pain由44.8%降至24.1%，FEV1效果不一致。
嘻嘻：TB後肺復健有效，老肺也能慢慢討回空間。
Financing the transition: a roadmap for sustaining disease control in low- and middle-income countries after the 2025 contraction in development assistance for health¶
Authors: Sriram S | Journal: Front Health Serv | Date: 2026
DOI: 10.3389/frhs.2026.1902705 | PMID: 42688228
TL;DR: 2025年development assistance for health單年下降約21%，美國financing減少67%，衝擊HIV、tuberculosis、malaria等計畫；roadmap主張先保frontline services，再以稅收、債務重整與pooled procurement銜接。
不嘻嘻：錢一縮，HIV、TB、malaria又被推去前線。
Fungal diseases in burn and blast-injured patients: tensions are rising, and awareness must keep pace¶
Authors: Dudoignon E et al. | Journal: Curr Opin Infect Dis | Date: 2026 Sep 02
DOI: 10.1097/QCO.0000000000001241 | PMID: 42687404
TL;DR: Burn與blast injury後IFD診治證據仍薄弱；近期重點包括burn-induced immunosuppression、quantitative PCR等分子診斷、source control加systemic antifungal therapy，並需依藥物動力學調整劑量。
不嘻嘻：burn與blast後真菌戰場，證據還在補破網。
Rates of azole resistance in aspergillosis: a worldwide overview¶
Authors: Wiederhold NP | Journal: Curr Opin Infect Dis | Date: 2026 Aug 27
DOI: 10.1097/QCO.0000000000001235 | PMID: 42687366
TL;DR: triazole-resistant Aspergillus fumigatus 已遍及各洲，臨床與環境樣本皆可見，常見 resistance mechanism 指向農業 azole 暴露；現有 prevalence 仍受小型短期研究與缺乏 surveillance 限制。
不嘻嘻：Aspergillus 也在環遊世界，藥櫃先冒冷汗。
🟢 One Health / Zoonoses¶
Extreme climatic events drive consistent and predictable shifts in soil antibiotic resistance genes¶
Authors: Xu G et al. | Journal: Proc Natl Acad Sci U S A | Date: 2026 Sep 08
DOI: 10.1073/pnas.2612278123 | PMID: 42691088
TL;DR: 30 個歐洲草原土壤模擬 drought、flooding、freeze-thaw、heatwaves 後，ARGs 變化小但一致；heatwaves 最明顯降低 ARG abundance 與 MGE linkages，random-forest 可預測組成反應。
嘻嘻：連熱浪都能幫我們上一堂 resistome 生態課。
Comparative genomic epidemiology of food- and patient-derived diarrheagenic Escherichia coli from sentinel surveillance in Southeast China¶
Authors: Huang X et al. | Journal: Int J Food Microbiol | Date: 2026 Aug 29
DOI: 10.1016/j.ijfoodmicro.2026.112029 | PMID: 42685492
TL;DR: 中國麗水 2018–2025 年 258 株 DEC 中，204 株做 WGS；food 與 patient isolates 在 genomic backgrounds、resistance determinants、42 種 plasmid replicons 有部分重疊，但不足以推論直接 transmission。
不嘻嘻：食物、人、plasmid 同場加映，線索多但兇手還沒現形。
Functional and mechanistic characterization of the phosphatidyl-myo-inositol mannosyltransferase PimA from Mycobacterium tuberculosis: implications for anti-tuberculosis drug development¶
Authors: Liu D et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1888373 | PMID: 42688155
TL;DR: Mycobacterium tuberculosis PimA 單體直徑 5.1 ± 0.2 nm；R196A、K202A、K256A 完全失活，GDP 40 µM 與 benzimidazole 10 µM 抑制逾 50%，PimA silencing 使 Mtb 易被 macrophage 清除。
嘻嘻：PimA 看起來像 Mtb 的阿基里斯腱，值得繼續追。
The Brucella effector protein BtpB facilitates STAT3 activation to regulate polarization in macrophages during infection¶
Authors: Yuan Y et al. | Journal: Vet Res | Date: 2026 Sep 02
DOI: 10.1186/s13567-026-01833-8 | PMID: 42687195
TL;DR: Brucella suis BtpB 在 RAW264.7 macrophages 抑制 M1、促進 M2 polarization，並上調 STAT3；STAT3 inhibition 增加 NOS2，overexpression 降低 NOS2，支持 BtpB 透過 STAT3 調控 macrophage response。
不嘻嘻：Brucella 連免疫劇本都會改，宿主只好照演。
Transferable optrA-mediated linezolid resistance in enterococci from high-altitude river sediments of Gilgit-Baltistan, Pakistan¶
Authors: Simoni S et al. | Journal: Appl Environ Microbiol | Date: 2026 Sep 02
DOI: 10.1128/aem.01129-26 | PMID: 42684862
TL;DR: 巴基斯坦 Gilgit-Baltistan 12 個高海拔河川沉積物點位中 3 點分離 17 株 florfenicol-resistant enterococci；4 株 optrA 全為 plasmid-borne，conjugation transfer frequency 達 2.03×10⁻⁶–6.36×10⁻⁴。
不嘻嘻：linezolid resistance 跑到高山河床，浪漫不起來。
Genomic epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli across humans, poultry and wastewater sectors in Douala, Cameroon¶
Authors: Djoko Nono A et al. | Journal: JAC Antimicrob Resist | Date: 2026 Oct
DOI: 10.1093/jacamr/dlag194 | PMID: 42688691
TL;DR: 喀麥隆 Douala 628 件樣本中 374 件有 ESBL-E. coli；孕婦 54.6%、雞 70.4%、廢水 93.1%，blood culture 陽性中 9.2%。WGS 32 株見 blaCTX-M-15、blaCTX-M-55、mcr-1、blaOXA-181。
不嘻嘻：One Health 監測一打開，抗藥性全員到齊。
Detection of Ehrlichia spp., Candidatus Neoehrlichia sp. (FU98) and Anaplasma phagocytophilum in red foxes (Vulpes vulpes) in Germany¶
Authors: Eggersmann A et al. | Journal: Ticks Tick Borne Dis | Date: 2026 Sep 02
DOI: 10.1016/j.ttbdis.2026.102708 | PMID: 42685537
TL;DR: 德國 537 件赤狐脾臟 PCR 中 Anaplasmataceae 陽性 3%（15 件），含 Candidatus Neoehrlichia sp. FU98 1.7%、Anaplasma phagocytophilum 0.9%、未知 Ehrlichia genotype 0.4%；未檢出 Rickettsia spp.。
嘻嘻：狐狸也在幫忙補 zoonosis 拼圖，野外監測有料。
'My dog is my life': One Health approaches to healthcare for people and their companion animals experiencing homelessness in the United Kingdom¶
Authors: Sullivan R et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0354517 | PMID: 42691039
TL;DR: 英國約一成尋求 shelter 的 homelessness population 有 companion animal；訪談顯示人與犬 healthcare needs 高度交織，共址服務可行但有顧慮，較可操作方向是 coordinated multi-species healthcare。
嘻嘻：醫療把人和狗一起看見，這才像真正的照護。
Gastro-intestinal parasites of camels (Camelus dromedarius) - a review¶
Authors: Rohilla S et al. | Journal: Vet Res Commun | Date: 2026 Sep 02
DOI: 10.1007/s11259-026-11473-0 | PMID: 42684585
TL;DR: 單峰駱駝常見 gastrointestinal parasites 包括 Haemonchus、Trichostrongylus、Strongyloides、Fasciola、Cryptosporidium、Toxoplasma gondii 等；prevalence 受年齡、氣候、飼養與診斷方法影響，anthelmintic resistance 增加 control 難度。
不嘻嘻：駱駝寄生蟲名單長到像值班交班，還會抗藥。
Lessons Learned During the 2024‒2025 Highly Pathogenic Avian Influenza A(H5N1) Virus Outbreak Response in the United States: The Experience of State and Local Public Health Departments¶
Authors: Meyer D et al. | Journal: Am J Public Health | Date: 2026 Sep 03
DOI: 10.2105/AJPH.2026.308656 | PMID: 42691445
TL;DR: 2025 年 8–11 月訪談美國 10 州 37 名衛生與農業部門人員，2024–2025 A(H5N1) response 主要困難為農場進入、risk population 觸及、zoonotic guidelines 不足與資源不確定。
不嘻嘻：H5N1 應變卡在農場門口，公衛又在靠意志力。
🟡 Food Security / Food Safety¶
The nutritional value of invertebrate aquatic foods¶
Authors: Zamborain-Mason J et al. | Journal: Nature | Date: 2026 Sep 02
DOI: 10.1038/s41586-026-10908-7 | PMID: 42686910
TL;DR: 整合 aquaculture、capture fisheries 與營養組成資料，水生無脊椎動物現有產量可供逾 50 億人 vitamin B12 與 selenium 年需求，並供逾 10 億人 copper、omega 3、iodine、zinc。
嘻嘻：海裡小東西意外很補，營養政策可以多看一眼。
Error-calibrated sensing: ratiometric biosensor for carcinogenic formaldehyde in food safety monitoring¶
Authors: Meliana C et al. | Journal: Food Chem | Date: 2026 Aug 27
DOI: 10.1016/j.foodchem.2026.150870 | PMID: 42685422
TL;DR: ratiometric formaldehyde biosensor 線性範圍 0.02–0.50 mM、LOD 0.004 mM，coffee samples recovery 97.22–103.87%、RSD 0.21%；與 Nash assay 相關性 R²=0.995，低濃度 0.02 mM accuracy 高達 9 倍。
嘻嘻：食安感測器校準到這麼穩，咖啡先安心一點。
Seasonal dynamics of microbial communities and potential human pathogens in Crassostrea hongkongensis and ambient water in southern China¶
Authors: Liu X et al. | Journal: Appl Environ Microbiol | Date: 2026 Sep 02
DOI: 10.1128/aem.01056-26 | PMID: 42684864
TL;DR: 中國南部北海與湛江 1 年季度採樣顯示，Crassostrea hongkongensis microbiota 12 月地點差異明顯；Vibrio 較常見於牡蠣組織，culturable Vibrio vulnificus 與 temperature、nitrate 呈負相關。
不嘻嘻：牡蠣和 Vibrio 的季節戀曲，吃生食請先冷靜。
Low-pass whole-genome sequencing reveals genomic diversity and ecotype-specific adaptation in indigenous Tigrayan chickens¶
Authors: Gebru G et al. | Journal: Sci Rep | Date: 2026 Sep 02
DOI: 10.1038/s41598-026-54932-z | PMID: 42686774
TL;DR: 衣索比亞 Tigray 33 隻 indigenous chickens 以 LP-WGS（0.2–1.99×）保留 2,340 萬 SNPs，約 17% 為 novel variants；highland diversity 最低且 inbreeding 較高，三種 ecotypes 呈明顯 genomic differentiation。
嘻嘻：雞的低深度 WGS 也能挖出適應演化，挺會省。
Cell recovery and DNA extraction methods skew relative abundance estimations of foodborne pathogens and spoilage organisms on stainless steel surfaces¶
Authors: Feng J et al. | Journal: Microbiol Spectr | Date: 2026 Sep 03
DOI: 10.1128/spectrum.03787-25 | PMID: 42690034
TL;DR: 不鏽鋼表面 swabbing recovery 差異大：vegetative cells 2.9%–6.6%、spores 35.2%–94.9%；等量起始時 L. monocytogenes 被低估至 9%–17%。
不嘻嘻：swab 一刷，病原排名也跟著變魔術。
Porcine epidemic diarrhea virus infection promotes Peyer's patch immune induction and epithelial defense via single-cell transcriptional reprogramming¶
Authors: Wiarda JE et al. | Journal: Microbiol Spectr | Date: 2026 Sep 02
DOI: 10.1128/spectrum.02643-25 | PMID: 42684955
TL;DR: PEDV infection 使空腸各細胞型 transcriptional reprogramming；mature enterocytes 為主要標的，190-gene antiviral signature 隨 enterocyte 成熟增強。
嘻嘻：PEDV 把腸道免疫劇本翻開給我們看了。
A plasmid-encoded T3SS underlies the virulence of enteropathogenic Providencia alcalifaciens strains isolated from a large foodborne outbreak in Japan¶
Authors: Hassan J et al. | Journal: Infect Immun | Date: 2026 Sep 01
DOI: 10.1128/iai.00151-26 | PMID: 42684853
TL;DR: 日本福井 1996 年 270 人 foodborne outbreak 的 P. alcalifaciens 帶 ~162 kb plasmid-encoded T3SS；T3SSp 與 PipA 對 epithelial invasion 與兔模型 diarrhea 必要。
不嘻嘻：Providencia 也帶外掛，食物中毒宇宙持續擴張。
Beyond the market: Food safety knowledge and practices among female household food handlers in the domestic kitchen¶
Authors: Essuman EK et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0356599 | PMID: 42685130
TL;DR: 迦納霍市 386 名女性家庭食物處理者雖有高 awareness，僅 42.2% 烹調前洗手、22.5% 規律清洗食材；大專教育預測較佳 knowledge（adjusted OR 3.66）。
不嘻嘻：知道歸知道，水龍頭前還是常常失守。
Impact of the Food4Moms produce prescription program on readiness for healthy eating, fruit and vegetable intake, and food security¶
Authors: Segura-Pérez S et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0348968 | PMID: 42685025
TL;DR: Food4Moms 提供低收入 Latina 孕婦每月 100 美元、10 個月 produce prescription；完成 endline 113 人，healthy eating readiness、蔬果攝取與 household food security 均改善。
嘻嘻：處方開蔬果，這種介入我願意多看幾篇。
Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1-derived exopolysaccharide suppresses murine norovirus replication by modulating innate immune response¶
Authors: Tang S et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0356886 | PMID: 42685021
TL;DR: Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 的 R-1 EPS 在 RAW264.7 細胞 post-infection treatment 降低 murine norovirus viral load，並增強 type I IFN 與 proinflammatory cytokines。
嘻嘻：優格菌的多醣看起來不只會賣萌。
Size-Selective Bubble-Array Acoustofluidic Separation Enables Colorimetric Detection of Salmonella¶
Authors: Zhu Y et al. | Journal: Anal Chem | Date: 2026 Sep 01
DOI: 10.1021/acs.analchem.6c03777 | PMID: 42689613
TL;DR: bubble-array acoustofluidic 平台結合 Au@Pt nanozyme colorimetric readout 偵測 Salmonella，線性範圍 8×10¹–8×10⁵ CFU/mL、LOD 26 CFU/mL；雞肉樣本 recovery 95.1%–101.4%。
嘻嘻：氣泡陣列加顯色，抓 Salmonella 很有戲。
Quantitative Surface-Enhanced Raman Spectroscopy Sensing of Salmonella and Listeria in a Food Matrix¶
Authors: Abed MM et al. | Journal: ACS Sens | Date: 2026 Aug 28
DOI: 10.1021/acssensors.6c02222 | PMID: 42687309
TL;DR: pHEMA-FON SERS 平台可在稀釋蘋果汁定量偵測 Salmonella typhimurium 與 Listeria monocytogenes，兩者 LOD 皆為 158 CFU/mL；sonication 可增強 species discrimination。
嘻嘻：果汁裡抓菌還能分身分，SERS 有點帥。
A Ce-Involved MOF@Nanozyme Probe Empowers Programmable Centrifugal Microfluidics for Integrated Immunoassay¶
Authors: Dong Y et al. | Journal: ACS Sens | Date: 2026 Aug 28
DOI: 10.1021/acssensors.6c01405 | PMID: 42687295
TL;DR: Ce/Zr-UiO 66@CeO2 nanozyme 整合 centrifugal microfluidic chip 可 28 分鐘偵測 Salmonella 至 46 CFU/mL，較 ELISA 敏感 2517 倍；food matrices recovery 80.67%–113.72%。
嘻嘻：28 分鐘出答案，食安檢測快得像開外掛。
Phenotypic and PCR-based analysis of antimicrobial resistance in heat-treated multidrug-resistant Salmonella spp. and Campylobacter jejuni isolated from raw chicken meat¶
Authors: Al-Qadiri HM et al. | Journal: Poult Sci | Date: 2026 Jul 23
DOI: 10.1016/j.psj.2026.107484 | PMID: 42685488
TL;DR: 生雞肉 MDR Salmonella spp. 與 Campylobacter jejuni 經 60°C heat treatment 後 phenotypic resistance 顯著下降，但 PCR 仍可偵測 ARG targets，顯示兩種 AMR 評估方法互補。
不嘻嘻：煮過看似變乖，ARG 還在旁邊冷笑。
資料來源：PubMed (articles retrieved 2026-09-04)