Daily Journal Digest — 2026-10-17¶
過去 24 小時新增:Transplant ID × 19、One Health × 15,共 34 篇。
⭐ 今日亮點¶
- Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy
整合免疫低下宿主 CMVR 的診斷與保視治療決策。 - Closing the Gap: Advances and Barriers on Candida Vaccines Development in the Last Decade
從抗藥性到免疫宿主困境,勾勒 Candida vaccine 轉譯全貌。
🔬 深入評讀¶
Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy¶
J Clin Med | DOI | PMID 42881944
- 設計:敘述性綜述,整合 HIV、器官移植、惡性腫瘤治療、標靶免疫抑制及先天免疫缺陷宿主的 CMVR 風險分層、診斷與治療框架。
- 樣本:未進行原始病人收案或系統性統合分析;納入文獻涵蓋不同地區與免疫抑制族群,但摘要未列出檢索策略、研究數或年代範圍。
- 關鍵論點:散瞳 retinal examination 與 serial imaging 是判定病灶活性及視力威脅的核心,診斷不確定時可輔以 ocular-fluid PCR;可行時以 systemic valganciclovir 或 ganciclovir 為治療骨幹,立即威脅視力病灶可加上 intravitreal therapy。
- Limitation:屬敘述性綜述,未說明系統性檢索、納入標準或偏差風險評估;不同免疫抑制族群與治療研究高度異質,HIV 以外宿主的維持治療停藥條件仍缺乏明確證據。
- Bottom line:對免疫低下病人的疑似 CMVR,應以眼底所見主導診斷與緊急程度判斷,並及早整合全身抗病毒與必要的眼內治療以保留視力。
Closing the Gap: Advances and Barriers on Candida Vaccines Development in the Last Decade¶
Int J Mol Sci | DOI | PMID 42883739
- 設計:2015–2025 年 Candida vaccine 發展的結構化敘述性綜述,涵蓋流行病學與抗藥性、免疫學基礎、抗原與遞送平台,以及臨床前和臨床證據。
- 樣本:未進行原始病人收案、系統性回顧或統合分析;摘要提及 NDV-3A 的 Phase II 臨床驗證、C. auris A/J mouse model 與多 epitopes 平台,但未提供各研究樣本數或追蹤資料。
- 關鍵論點:綜述指出 invasive candidiasis 每年估計 25 萬至 70 萬例、死亡率 40% 至 55%,並將 NDV-3A Phase II、跨物種保護概念及 HLA population coverage 超過 94% 的多 epitopes 平台列為近十年進展;但尚無核准的 antifungal vaccine。
- Limitation:屬敘述性綜述,未交代系統性檢索、納入研究數、偏差風險或證據確定性;臨床驗證仍有限,且免疫低下宿主的疫苗反應、Candida 的 commensal-to-pathogen duality 與 antigenic plasticity 均限制可轉譯性。
- Bottom line:Candida vaccine 已出現具潛力的平台與早期臨床訊號,但真正需要保護的免疫低下宿主仍是其最關鍵、尚未解決的轉譯考驗。
🔴 Transplant & Opportunistic Infections¶
FKS1/2-variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infections¶
Authors: Gifford H et al. | Journal: Nat Commun | Date: 2026 Oct 15
DOI: 10.1038/s41467-026-76954-x | PMID: 42881167
TL;DR: 倫敦2名重症患者的連續分離株顯示,FKS1/2 wild-type Candida auris 可經 heteroresistance、polyploidy(≥4n)、細胞壁 β-1,3-glucan 改變與 CRZ1 突變逐步提高 echinocandin MIC。
不嘻嘻:C. auris 又示範了不靠 FKS 也能把治療逼進死角。
Inhibition of Porcine Cytomegalovirus/Porcine Roseolovirus (PCMV/PRV) Replication with Antiviral Compounds¶
Authors: Mei H et al. | Journal: Antiviral Res | Date: 2026 Oct 15
DOI: 10.1016/j.antiviral.2026.106554 | PMID: 42880643
TL;DR: 體外抑制 PCMV/PRV 最有效者為 brincidofovir(EC50 0.01 μM)、cidofovir(1.65 μM)與 cyclopropavir(2.13 μM);ganciclovir 活性較弱,acyclovir、maribavir、letermovir 與 pritelivir 無活性或活性降低。
嘻嘻:豬病毒至少還有幾張可用的 antiviral 牌。
Serum hepcidin as a host-derived biomarker of disease severity and risk stratification in tuberculosis¶
Authors: Kaushik U et al. | Journal: Infection | Date: 2026 Oct 15
DOI: 10.1007/s15010-026-03020-5 | PMID: 42878786
TL;DR: 140名 tuberculosis 患者中,重症者 serum hepcidin 較高(201.5 vs. 145.9 ng/mL,p=0.017),但與3個月死亡無關;死亡預測以 ADA/CK-MB 最佳(AUC 0.82),整體死亡率22.1%。
不嘻嘻:hepcidin 很會報警,卻還沒學會預告結局。
Host receptor-mediated responses to Candida albicans: An update¶
Authors: Zhu H et al. | Journal: Med Mycol | Date: 2026 Oct 15
DOI: 10.1093/mmy/myag111 | PMID: 42878694
TL;DR: 此綜述整理宿主辨識 Candida albicans 細胞壁 β-glucan、chitin 與 mannan 的 receptors;Dectin-1/2/3、Mincle、MR 等直接辨識,而 TLR2/4、EphA2/B2 等協助辨識並啟動 innate immune responses。
嘻嘻:宿主辨識 C. albicans 的防線,拼圖愈來愈完整。
HLA-driven variability in human cytomegalovirus immune recognition: Epitope predictions from a kidney transplant Cohort¶
Authors: Moreno Rosado MD et al. | Journal: PLoS One | Date: 2026
DOI: 10.1371/journal.pone.0360632 | PMID: 42879396
TL;DR: 秘魯562名 kidney transplant candidates 與相關 donors 的 HLA 分型辨識16種常見 HLA-I、10種 HLA-II allele groups,並預測954個 HCMV HLA-I epitopes,其中169個對應既有 IEDB epitopes;免疫原性仍待實驗驗證。
嘻嘻:HLA 地圖先鋪好,HCMV 精準免疫策略有路可走。
The association between viral infections and aplastic anemia: a comprehensive scoping review¶
Authors: Ghahvechi H et al. | Journal: Crit Rev Clin Lab Sci | Date: 2026 Oct 16
DOI: 10.1080/10408363.2026.2735636 | PMID: 42886030
TL;DR: 納入48篇研究的 scoping review 指出 parvovirus B19、EBV、CMV、HIV、hepatitis viruses、HTLV-1 與 SARS-CoV-2 均與 aplastic anemia 相關,可能涉及骨髓直接抑制、immune-mediated destruction 或 immunosuppression 下 viral reactivation。
不嘻嘻:病毒與 aplastic anemia 的關係,仍像一團很難拆的毛線。
Neurological Manifestations in People Living with Human Immunodeficiency Virus (PLHIV) in India: A Scoping Review and the Need for a National HIV-Neurology Special Interest Group¶
Authors: Mustafa F et al. | Journal: Ann Indian Acad Neurol | Date: 2026 Oct 16
DOI: 10.4103/aian.aian_197_26 | PMID: 42885970
TL;DR: 印度148篇研究、3,433名 HIV 感染者中,94.7%為中樞神經系統病變,74.83%病因為 opportunistic infections;meningitis 最常見(1,187例),Cryptococcus 與 Mycobacterium tuberculosis 為最常見病原。
不嘻嘻:HIV 神經併發症仍多由伺機性感染搶戲,實在笑不出來。
Thoracic Pathologies Requiring Surgical or Interventional Management in Solid-Organ Transplant Recipients¶
Authors: Yucemen AU et al. | Journal: Exp Clin Transplant | Date: 2026 Sep
DOI: 10.6002/ect.2026.0249 | PMID: 42885708
TL;DR: 21名 solid-organ transplant recipients 共接受28次 thoracic interventions,病灶涵蓋 pleural、parenchymal 與 mediastinal compartments;9.5%發生術後併發症,病理包括 aspergilloma、tuberculosis、惡性腫瘤及 post-transplant lymphoproliferative disease。
不嘻嘻:transplant 後的胸腔病灶,連外科都得一起加班。
Posttransplant Tubulointerstitial Nephritis in Kidney Recipients: From Bacteria to BK Virus: A 24-Year Single-Center Analysis of Etiology, Timing, and Graft Survival¶
Authors: Tepeoglu M et al. | Journal: Exp Clin Transplant | Date: 2026 Sep
DOI: 10.6002/ect.2025.0164 | PMID: 42885703
TL;DR: 1,445名 kidney transplant recipients 中209例 biopsy-proven tubulointerstitial nephritis,以 bacterial 最常見(50.7%);合併 antibody-mediated rejection 或持續發炎/viremia 顯著降低10年 graft survival,viral 病例10年存活率為0%。
不嘻嘻:病毒相關腎炎的長期 graft 預後,冷得像冰庫。
Fungi in Asthma: From Epidemiology and Airway Mycobiome to Molecular Mechanisms and Novel Allergenic Phytopathogens¶
Authors: Krasowska-Kunach M et al. | Journal: Int J Mol Sci | Date: 2026 Sep 27
DOI: 10.3390/ijms27198639 | PMID: 42883886
TL;DR: 真菌暴露、sensitization 與 asthma severity 相關,但 airway mycobiome 多為關聯性證據。ABPA 可使用 antifungal treatment;SAFS 的證據不一致,biologic 應依臨床 phenotype 與既定適應症選擇。
不嘻嘻:asthma 的真菌故事很熱鬧,但可用答案還是不夠多。
Closing the Gap: Advances and Barriers on Candida Vaccines Development in the Last Decade¶
Authors: Krier J et al. | Journal: Int J Mol Sci | Date: 2026 Sep 23
DOI: 10.3390/ijms27198490 | PMID: 42883739
TL;DR: Invasive candidiasis 每年估計25萬至70萬例,死亡率40%至55%;近10年 Candida vaccine 進展包括 NDV-3A Phase II 與多 epitopes 平台,但仍受 commensal-to-pathogen duality、免疫低下宿主與 antigenic plasticity 限制。
嘻嘻:Candida vaccine 終於持續往臨床推進,不再只是夢想。
Diagnostic Accuracy of a Novel Chemiluminescent Immunoassay for Strongyloides stercoralis in a Non-Endemic Clinical Setting¶
Authors: Roose S et al. | Journal: Diagnostics (Basel) | Date: 2026 Oct 06
DOI: 10.3390/diagnostics16193227 | PMID: 42882382
TL;DR: 義大利非流行地區245份血清以 Bayesian latent class analysis 評估,Strongyloides stercoralis VirClia® IgG monotest sensitivity 為95.0%(95% CrI 90.1–98.2%)、specificity 為90.8%(95% CrI 85.1–96.0%)。
嘻嘻:非流行區也有可靠篩檢,少讓 S. stercoralis 躲著偷笑。
Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy¶
Authors: Su S et al. | Journal: J Clin Med | Date: 2026 Sep 25
DOI: 10.3390/jcm15197482 | PMID: 42881944
TL;DR: CMVR 的診斷以散瞳 retinal examination 與 serial imaging 為核心,ocular-fluid PCR 用於診斷不確定者。可行時以 systemic valganciclovir 或 ganciclovir 治療;立即威脅視力的病灶可加用 intravitreal therapy。
嘻嘻:守住 CMVR 的視力,及早辨識永遠值得。
Intravesical Allogeneic Platelet Concentrate for Refractory BK Virus-Associated Haemorrhagic Cystitis After Allogeneic Haematopoietic Stem Cell Transplantation¶
Authors: Güleser AS et al. | Journal: J Clin Med | Date: 2026 Sep 24
DOI: 10.3390/jcm15197407 | PMID: 42881869
TL;DR: 14名 Grade 3–4 BKV-HC 且既有治療失敗的 allo-HSCT 患者接受 intravesical allo-PC 後,12人(85.7%)macroscopic haematuria 消退,中位5.5天;platelet concentration 與消退時間呈強負相關(rs=-0.917)。
嘻嘻:難纏 BKV-HC 出血,竟有個相當俐落的止血新招。
Alternate-Day Versus Consecutive-Day Anti-T Lymphocyte Globulin Induction in First Living-Donor Kidney Transplant Recipients at Low Immunological Risk: A Retrospective Cohort Study¶
Authors: Yilmaz G et al. | Journal: J Clin Med | Date: 2026 Sep 22
DOI: 10.3390/jcm15197348 | PMID: 42881811
TL;DR: 195名低免疫風險首次 living-donor kidney transplant recipients 中,alternate-day 與 consecutive-day ATLG 的1年 bacterial infection 相近(50.5% vs. 50.0%);給藥時程非獨立預測因子(adjusted OR 1.21,95% CI 0.64–2.30)。
嘻嘻:ATLG 怎麼排班都差不多,至少臨床安排多點彈性。
Post-Transplant Lymphoproliferative Disorder After Successful Treatment of Graft-Versus Host Disease Following Liver Transplantation¶
Authors: Yılmaz TU et al. | Journal: Transplant Proc | Date: 2026 Oct 15
DOI: 10.1016/j.transproceed.2026.09.018 | PMID: 42881047
TL;DR: 65歲男性LDLT後第3個月診斷GVHD,接受高劑量類固醇與extracorporeal photopheresis;第11個月出現PTLD,以Rituxima、ruxolitinib治療後仍存活且performance良好。
嘻嘻:免疫風暴後還能穩住,這位病人的韌性值得全場起立鼓掌。
Successful First-Line Haploidentical Hematopoietic Stem Cell Transplantation in an Elderly Patient With Severe Aplastic Anemia and Complex Comorbidities: A Case Report¶
Authors: Sun Y et al. | Journal: Transplant Proc | Date: 2026 Oct 15
DOI: 10.1016/j.transproceed.2026.09.011 | PMID: 42881045
TL;DR: 62歲SAA女性接受前線haplo-HSCT合併UC-MSCs,neutrophil engraftment於+12天、血小板獨立於+13天,+14天donor chimerism達99.6%。移植約17個月無chronic GVHD,CMV感染經maribavir控制。
嘻嘻:高齡複雜個案也能漂亮過關,移植團隊今天可以多喝一杯咖啡。
Temporal trends in transfusion-transmitted cytomegalovirus infection among cytomegalovirus-seronegative HSCT recipients¶
Authors: Yakushijin K et al. | Journal: Int J Hematol | Date: 2026 Oct 15
DOI: 10.1007/s12185-026-04295-y | PMID: 42878984
TL;DR: 日本5,016名CMV-seronegative HSCT受者中,random donor血品與TT-CMV(OR 2.35)及csCMVi(SHR 2.22)相關。2021–2022年TT-CMV降至12.7%、100日csCMVi降至8.3%,與CMV-seronegative血品差異已不顯著。
嘻嘻:TT-CMV逐年下降,血庫與移植照護的努力終於有回音。
Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Maternal Plasma and Breast Milk & Infant Cord Blood and Plasma: A Model-Based Analysis of Mother-Infant Pairs for Tuberculosis Prevention¶
Authors: Jayachandran P et al. | Journal: Clin Pharmacol Ther | Date: 2026 Oct 15
DOI: 10.1002/cpt.70479 | PMID: 42878247
TL;DR: Rifapentine與desacetyl rifapentine在母乳/母體血漿濃度比分別為0.0236與0.0411,最大relative infant dose低於1%。母體給藥72小時內,Rifapentine可經胎盤進入嬰兒血漿,但濃度推估無臨床意義。
嘻嘻:預防結核不必讓母嬰安全二選一,這份PK讓人安心不少。
🟢 One Health / Zoonoses¶
ICAM-1 functions as a functional receptor for encephalomyocarditis virus and reveals a compensatory interplay with ICAM-4¶
Authors: Hou Z et al. | Journal: Cell Rep | Date: 2026 Oct 15
DOI: 10.1016/j.celrep.2026.118155 | PMID: 42879278
TL;DR: ICAM-1可直接高親和力結合EMCV VP1與VP2,soluble ICAM-1 fusion protein或anti-ICAM-1 antibody均抑制人類與小鼠細胞感染。ICAM-4則在ICAM-1 knockout/knockdown模型補償作為EMCV受體。
嘻嘻:EMCV找到了新門票,阻斷感染的靶點又多了一扇窗。
Characterization of the Peromyscus leucopus immunoglobulin germline repertoire and anti-OspA antibody response reveals conserved germline IGHV features among cricetid rodents¶
Authors: Zhou Y et al. | Journal: mSphere | Date: 2026 Oct 16
DOI: 10.1128/msphere.00473-26 | PMID: 42885934
TL;DR: Peromyscus leucopus具12個IGHV、12個IGKV與3個IGLV gene families,分別含129、87、12個基因。逾140個anti-OspA IGHV分析顯示,相關germline IGHV與其他易感Borrelia鼠科動物的序列相似性較高。
嘻嘻:從鼠類抗體庫挖線索,Lyme disease疫苗研發或許有新地圖。
The Qing Chang Hua Shi Formula combined with allicin alleviates Cryptosporidium parvum infection in immunosuppressed mice and is associated with restoration of NLRP6, IL-18, IFN-γ, and intestinal microbiota¶
Authors: Xu C et al. | Journal: Microbiol Spectr | Date: 2026 Oct 16
DOI: 10.1128/spectrum.03662-25 | PMID: 42885911
TL;DR: QHF合併allicin在體外抑制逾90% Cryptosporidium parvum,immunosuppressed mice治療8天後糞便oocyst shedding降至model group的12.88%。治療伴隨NLRP6、IL-18、IFN-γ及腸道菌相改變,但作用機制仍待驗證。
嘻嘻:Cryptosporidium終於遇到對手,但機轉這關仍得老實補考。
Emergence of ESBL-Producing Escherichia coli in Shrimp Aquaculture, Kerala, India¶
Authors: Patel A et al. | Journal: Ecohealth | Date: 2026 Oct 15
DOI: 10.1007/s10393-026-01852-z | PMID: 42881343
TL;DR: 印度喀拉拉邦63座蝦養殖場、206份檢體分離50株ESBL-producing Escherichia coli,全數為MDR,MAR index為0.32–0.64。blaCTX-M-gp-1占86%,且PFGE顯示高度genetic heterogeneity,支持非clonal傳播。
不嘻嘻:蝦池養出MDR,海鮮拼盤也開始替感染科出考題。
ZOOJEU: Using Q fever to highlight a participatory science approach for fostering the co-design of management strategies for neglected zoonotic diseases¶
Authors: Jourdain E et al. | Journal: PLoS Negl Trop Dis | Date: 2026 Oct
DOI: 10.1371/journal.pntd.0014618 | PMID: 42879425
TL;DR: 法國西部Q fever山羊流產情境中,ZOOJEU以漫畫與serious game納入農民等利害關係人;23名參與者分3組共同分析案例。此participatory science方法可建立共享敘事並促進共同設計公共衛生策略。
嘻嘻:防治人畜共通感染不能只靠專家,讓在地聲音入場才走得遠。
Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay¶
Authors: de Souza Rabello VB et al. | Journal: Mycopathologia | Date: 2026 Oct 15
DOI: 10.1007/s11046-026-01113-1 | PMID: 42878983
TL;DR: 巴西、阿根廷與巴拉圭92株Sporothrix brasiliensis分為6個genotypes;各抗真菌藥的non-wild-type株分布於4個haplotypes,未限於特定genetic background。此類株較常見於巴西米納斯吉拉斯州H2 feline isolates。
不嘻嘻:Sporothrix不按基因背景出牌,抗真菌藥敏感性又添一層迷霧。
Strategic Prevention of Occupational and Toxicological Risks in Moroccan Traditional Tanneries: From Risk Assessment to Operational Health and Safety Planning¶
Authors: Arhoune I et al. | Journal: Health Promot Pract | Date: 2026 Oct 16
DOI: 10.1177/15248399261490871 | PMID: 42885846
TL;DR: 摩洛哥非斯傳統皮革廠2017–2019年基準資料與2025年實務比較顯示,PPE使用、衛生條件及醫療監測已有改善,但勞工仍常回報皮膚、呼吸、泌尿與肌肉骨骼症狀。研究提出整合式職業安全預防計畫。
嘻嘻:職業衛生終於從報告走向現場,工人的肺和皮膚都在等這一步。
Characteristics of Staphylococcus haemolyticus Isolated from Humans and Animals¶
Authors: Prorok P et al. | Journal: Int J Mol Sci | Date: 2026 Oct 07
DOI: 10.3390/ijms27198905 | PMID: 42884148
TL;DR: 113株人類與伴侶動物來源的Staphylococcus haemolyticus中,45.13%為MDR;35株WGS顯示高度genomic diversity,未依宿主或臨床狀態明確分群。39°C時biofilm formation明顯增加,且抗藥基因無法一致預測phenotype。
不嘻嘻:S. haemolyticus又多樣又會biofilm,實驗室看了只能深呼吸。
Early-Life Oat Supplementation Is Associated with Altered Cecal Microbiota and Microbial Metabolic Profiles and Reduced Campylobacter jejuni Colonization in Broiler Chickens¶
Authors: Dessalegn B et al. | Journal: Int J Mol Sci | Date: 2026 Sep 26
DOI: 10.3390/ijms27198607 | PMID: 42883855
TL;DR: 肉雞早期補充10% oat的MDF組,在35 dpi使盲腸Campylobacter jejuni量最多下降3.3 log10 CFU/g,並減少肝臟與脾臟dissemination。效果伴隨盲腸microbiota、isobutyrate及迴腸胺基酸profile改變。
嘻嘻:燕麥不只當早餐,還可能替雞群守住腸道防線。
Characteristics of Staphylococcus epidermidis Isolated from Humans and Animals¶
Authors: Prorok P et al. | Journal: Int J Mol Sci | Date: 2026 Sep 25
DOI: 10.3390/ijms27198585 | PMID: 42883836
TL;DR: 320株人類、貓與犬來源的Staphylococcus epidermidis,oxacillin、erythromycin、tetracycline與clindamycin抗藥率分別為67.19%、66.56%、55.63%與53.75%。67株WGS具26種ST,未依宿主或臨床狀態完全分群。
不嘻嘻:S. epidermidis的抗藥性很有存在感,污染還是感染更難判了。
Low-Temperature Transcriptional Responses in Selected pESI-Positive Salmonella Infantis Isolates with Contrasting Antimicrobial Resistance Phenotypes: An Exploratory Study¶
Authors: Telli AE et al. | Journal: Foods | Date: 2026 Oct 01
DOI: 10.3390/foods15193512 | PMID: 42883618
TL;DR: 6株pESI-positive Salmonella Infantis在4°C下,susceptible組5個target genes平均表現均下降,MDR組則均上升;-20°C時MDR組亦全數上升。ipfA存在顯著temperature-by-phenotype interaction(p=0.029),但需更大樣本驗證。
不嘻嘻:冰箱沒有讓MDR安靜下來,連剩菜都替我們保存麻煩。
Probiotics as a Barrier Against Salmonella enterica and Escherichia coli in Contaminated Rice-Protein-Based Infant Formulas¶
Authors: Moreno-Muñoz JA et al. | Journal: Foods | Date: 2026 Sep 28
DOI: 10.3390/foods15193477 | PMID: 42883584
TL;DR: 112份樣本於1或10 CFU/10 g低接種量下培養18小時,未加 probiotics 時 E. coli 與 Salmonella enterica 相對豐度明顯上升;加入兩株 probiotics 後,多數條件下病原降至未檢出或<1%。
嘻嘻:嬰兒配方的 probiotics 終於不只是腸道玄學,還能幫忙守門。
Enrichment-Free Salmonella Quantification in Raw Poultry at the 1 and 10 CFU/g Decision Thresholds: A Multi-Laboratory Evaluation of the Pathotrak Concentrator with Real-Time PCR¶
Authors: Capobianco JA et al. | Journal: Foods | Date: 2026 Sep 26
DOI: 10.3390/foods15193441 | PMID: 42883548
TL;DR: Pathotrak concentrator 結合 real-time PCR 於313次接種、3間實驗室評估中,10 CFU/g門檻外分類正確率94.9%,敏感度100%、特異度94.4%;1 CFU/g分類正確率93.2%,皆可於單一工作班完成。
嘻嘻:一個工作班就判讀低菌量,食安實驗室終於能早點下班。
Emerging Biocontrol Strategies in Cheese Safety: A Critical Review of Bacteriophages, Antimicrobial Peptides, and Postbiotics¶
Authors: Pisana C et al. | Journal: Foods | Date: 2026 Sep 25
DOI: 10.3390/foods15193435 | PMID: 42883542
TL;DR: Cheese生物防治中,bacteriophages、AMPs/bacteriocins與postbiotics各受低溫、酸性pH、脂肪基質或效力變異限制;多重hurdle與表面投遞優於單一介入,仍需標準化全保存期限challenge trial驗證。
不嘻嘻:起司的生物防治選項不少,但每個都還有自己的脾氣。
Manifestations of Salmonellosis in Small Ruminants in The Netherlands over a Period of 15 Years¶
Authors: Snijders-van de Burgwal N et al. | Journal: Animals (Basel) | Date: 2026 Sep 26
DOI: 10.3390/ani16193031 | PMID: 42883000
TL;DR: 荷蘭2006–2020年共在25個羊場檢出34例、14個羊場檢出42例羊與山羊 salmonellosis;山羊病例2013年後增加且多見於新生期,Salmonella Typhimurium outbreak 與人類接觸感染凸顯 One Health 風險。
不嘻嘻:S. Typhimurium 又跨物種添亂,One Health 加班。
資料來源:PubMed (articles retrieved 2026-10-17)