Daily Journal Digest — 2026-10-24¶
過去 24 小時新增：Transplant ID × 24、One Health × 15，共 39 篇。
⭐ 今日亮點¶
- Hypoxemia and pulmonary infiltrates during T-cell-engaging bispecific antibody therapy: A pulmonary and critical care framework
補足 BsAbs 肺部併發症的床邊鑑別框架。
🔬 深入評讀¶
Hypoxemia and pulmonary infiltrates during T-cell-engaging bispecific antibody therapy: A pulmonary and critical care framework¶
Respir Investig | DOI | PMID 42914683
- 設計：聚焦敘述性綜述，整合 pivotal trials、藥品仿單、共識聲明、真實世界研究及肺部醫學文獻；摘要未說明系統性檢索策略、資料庫或檢索期間。
- 樣本：非原始研究，未提供單一研究樣本數或追蹤期；涵蓋接受 T-cell-engaging bispecific antibodies（BsAbs）的復發或難治性多發性骨髓瘤、B-cell lymphomas 與 small-cell lung cancer 病人。
- 關鍵論點：作者提出兩個重疊風險時窗：step-up dosing 早期須平行評估與處置 CRS 及 infection；長期或持續治療時，infection、target-specific immune deficits 與非感染性 mimics 較重要。以氧氣需求軌跡、CT pattern、宿主免疫缺損、microbiologic data 與選擇性 bronchoscopy 組成的時間導向框架，可協助處理 PJP、CMV、呼吸道病毒、肺水腫、肺栓塞、腫瘤肺部侵犯及疑似藥物性肺損傷等鑑別診斷；未提出可統合的效果量。
- Limitation：屬敘述性綜述，未交代系統性檢索、納入標準、研究品質評估或證據分級，易受選文與專家詮釋影響；所提框架尚需前瞻性驗證其對診斷時效、抗感染治療適切性或 ICU outcome 的影響。
- Bottom line：對接受 BsAbs 且出現低氧與肺浸潤的病人，應依治療時窗並行排除 CRS 與 infection，避免過早錨定單一診斷。
🔴 Transplant & Opportunistic Infections¶
Mucormycosis in critically ill patients: a 9-year multicenter cohort study of clinical features, management, and 90-day outcomes¶
Authors: Bidar F et al. | Journal: Crit Care | Date: 2026 Jul 31
DOI: 10.1186/s13054-026-06227-y | PMID: 42919407
TL;DR: 43名ICU mucormycosis患者90日死亡率47%；高齡、hematological malignancy及較高SOFA score獨立相關於死亡。39人接受antifungal therapy，liposomal amphotericin B首線占74%。
不嘻嘻：mucormycosis進ICU，死亡率依舊很會教人謙卑。
Disseminated Nontuberculous Mycobacterial Disease in NEMO and Iκbα Defects¶
Authors: Wang C et al. | Journal: Clin Infect Dis | Date: 2026 Oct 22
DOI: 10.1093/cid/ciag602 | PMID: 42910636
TL;DR: NEMO（IKBKG）與IκBα（NFKBIA）缺陷可在成人出現disseminated nontuberculous mycobacterial disease，診斷常延遲；即使使用多重抗菌藥及IFN-γ，治療反應仍常不足。
不嘻嘻：免疫缺陷撞上NTM，治療選項看起來也很缺陷。
Predictors and Patterns of Metastatic Candidozyma auris Infection, Spain, 2016-2024¶
Authors: Suarez-Urquiza P et al. | Journal: Emerg Infect Dis | Date: 2026 Nov
DOI: 10.3201/eid3211.260984 | PMID: 42909852
TL;DR: 西班牙108名Candidozyma auris candidemia患者中，24人（22.2%）有metastatic infection，以endocarditis最常見（7.4%）。心臟裝置或prosthetic valve增加風險（HR 2.89），且metastatic infection提高60及90日死亡。
不嘻嘻：candidemia還會遠端擴散，臨床查房又多一輪尋寶。
Fungal representation in the environment of penguin communities in the French Southern territories¶
Authors: Desoubeaux G et al. | Journal: Med Mycol | Date: 2026 Oct 22
DOI: 10.1093/mmy/myag112 | PMID: 42910902
TL;DR: 法屬南部領地Crozet群島企鵝棲地的fungal load呈明顯季節性，繁殖育雛期達3–1,100 CFU/月，4月後平均降至150 CFU/月。Aspergillus fumigatus genotype多樣，未見antifungal resistance。
嘻嘻：企鵝棲地的Aspergillus暫未抗藥，難得安心。
Comparative Proteomics of Extracellular Vesicles of Two Species of Mucorales Reveals Species-Specific Cargo¶
Authors: Zhao T et al. | Journal: Mycopathologia | Date: 2026 Oct 23
DOI: 10.1007/s11046-026-01118-w | PMID: 42909754
TL;DR: Rhizopus arrhizus與Mucor irregularis extracellular vesicles有246種protein呈species-specific差異；小鼠足墊感染中前者造成較嚴重病灶，而後者EV在RAW 264.7 macrophages誘發較高pro-inflammatory cytokine表現。
嘻嘻：Mucorales的EV各有脾氣，靶點探索有戲。
Berberine-fluconazole synergy against drug-resistant Candida albicans: association with disruption of the Ire1-mediated UPR pathway¶
Authors: Yue D et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1965937 | PMID: 42920692
TL;DR: berberine合併fluconazole對drug-resistant Candida albicans具synergistic antifungal及antibiofilm活性，並擾亂ER homeostasis、減弱Ire1-mediated UPR，伴隨autophagy-related變化；確切機轉仍待釐清。
嘻嘻：老藥搭berberine，或許能讓抗藥性少囂張一點。
Hospitalization Patterns Among People Living with HIV During India's Transition to Universal Antiretroviral Therapy Access, 2013-2017¶
Authors: Jereen AA et al. | Journal: AIDS Res Hum Retroviruses | Date: 2026 Oct 23
DOI: 10.1177/08892229261500900 | PMID: 42920290
TL;DR: 印度1,280名HIV患者共2,157次住院中，AIDS-defining illness占45%，tuberculosis最常見（18%）。ART持續至少9個月與較低AIDS-defining住院勝算相關（aOR 0.78，95% CI 0.61–0.99）。
嘻嘻：穩定ART能少住院，最樸實的好消息。
Longitudinal real-time PCR monitoring of CMV DNAemia and renal function in living-donor kidney transplant recipients with low immunological risk¶
Authors: Gülteki̇n M et al. | Journal: BMC Nephrol | Date: 2026 Oct 21
DOI: 10.1186/s12882-026-05460-5 | PMID: 42920107
TL;DR: 112名低immunological risk活體腎移植受者中，25.9%出現CMV DNAemia；第6月serum creatinine較無DNAemia者高（1.38 vs. 1.17 mg/dL，p=0.047），但GFR差異未達統計顯著。
不嘻嘻：CMV DNAemia過後，腎功能還是留下些小帳單。
18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography in Pediatric Non-oncological Conditions: A Comprehensive Review¶
Authors: Ganapathy C et al. | Journal: PET Clin | Date: 2026 Oct 23
DOI: 10.1016/j.cpet.2026.09.005 | PMID: 42919721
TL;DR: 此review指出18F-FDG PET/CT在兒童非腫瘤疾病的應用擴大，包括drug-refractory epilepsy與focal cortical dysplasia等神經疾病。考量兒童較高radiosensitivity，應依ALARA原則降低tracer activity及CT劑量。
嘻嘻：PET/CT愈能幫忙，也更要替孩子守住輻射額度。
Vulvar infection caused by Histoplasma capsulatum: case report and literature review¶
Authors: Vioque F et al. | Journal: Enferm Infecc Microbiol Clin (Engl Ed) | Date: 2026 Oct 23
DOI: 10.1016/j.eimce.2026.503277 | PMID: 42919720
TL;DR: 西班牙首例外陰部Histoplasma capsulatum感染為38歲advanced HIV女性，病灶疑似carcinoma，經histopathology、culture及molecular techniques確認為H. capsulatum var. duboisii。文獻共4例，皆接受antifungal therapy且預後良好。
嘻嘻：偽裝成carcinoma的罕見感染，總算被揪出來。
Antifungal resistance landscapes in major fungal pathogens in Zhejiang, China¶
Authors: Wang H et al. | Journal: Fungal Biol Biotechnol | Date: 2026 Oct 22
DOI: 10.1186/s40694-026-00223-1 | PMID: 42919349
TL;DR: 中國浙江110株臨床Aspergillus isolates中，A. fumigatus azole resistance率8.6%，半數具TR34/L98H；另8.6%對amphotericin B resistant。轉錄體顯示ergosterol biosynthesis與efflux transporter基因上調，提示替代性resistance mechanism。
不嘻嘻：azole與amphotericin B都失守，真菌又在加考題。
Structure-Activity Relationship Profiling of Substituted N-Phthalimidopiperidine Analogs as Broad-Spectrum Antifungal Agents¶
Authors: Dupuis MP et al. | Journal: J Med Chem | Date: 2026 Oct 08
DOI: 10.1021/acs.jmedchem.6c01467 | PMID: 42917903
TL;DR: 新型N-phthalimidopiperidine analog SSD2032594對Candida auris、Cryptococcus neoformans、Aspergillus fumigatus及Mucormycosis-causing species的MIC為1–4 μg/mL，並在C. auris線蟲感染模型提高約30%存活率。
嘻嘻：廣效新分子初露頭角，抗黴菌武器庫有望補貨。
Peptide G3 Suppresses Hyphal Development in Candida albicans by Disrupting β-1,3-Glucan¶
Authors: Zhang Y et al. | Journal: Langmuir | Date: 2026 Oct 06
DOI: 10.1021/acs.langmuir.6c02457 | PMID: 42917691
TL;DR: peptide G3藉結合Candida albicans細胞壁β-1,3-glucan抑制yeast-to-hypha transition，30 μM可完全抑制。其造成細胞壁重塑，Congo red偵測的β-1,3-glucan signal降至48.2%，並抑制生長及hyphal transformation。
嘻嘻：卡住hypha形成，Candida的變身戲先喊停。
Antimicrobial Peptoids Show Potent Antifungal Activity against Candidozyma (Candida) auris In Vivo and Broad-Spectrum Activity In Vitro against Other Candida Species¶
Authors: Ryan LK et al. | Journal: ACS Infect Dis | Date: 2026 Oct 09
DOI: 10.1021/acsinfecdis.6c00525 | PMID: 42917104
TL;DR: TM4與TM5 peptoids對10株Candidozyma auris及6種其他Candida具活性，TM5最低MIC為4 μg/mL；小鼠systemic candidiasis模型中，感染後3小時給予TM5 5 mg/kg，24小時腎臟CFU顯示infection clearing。
嘻嘻：peptoid在小鼠清菌，C. auris終於有點壓力。
Hypoxemia and pulmonary infiltrates during T-cell-engaging bispecific antibody therapy: A pulmonary and critical care framework¶
Authors: Shiari A et al. | Journal: Respir Investig | Date: 2026 Oct 22
DOI: 10.1016/j.resinv.2026.101528 | PMID: 42914683
TL;DR: 接受T-cell-engaging BsAbs者，step-up dosing早期應同時評估CRS與infection；長期治療則以infection、target-specific immune deficits及非感染性mimics為主。氧氣變化、CT pattern、microbiologic data及選擇性bronchoscopy可協助鑑別。
嘻嘻：BsAbs低氧有鑑別框架，至少不用全靠祈禱。
Bronchoscopic phenotypes and anatomical airway involvement in invasive tracheobronchial aspergillosis without classic immunosuppression: association with in-hospital mortality¶
Authors: Nguyen-Cong HA et al. | Journal: Infect Dis (Lond) | Date: 2026 Oct 22
DOI: 10.1080/23744235.2026.2751508 | PMID: 42914555
TL;DR: 31例無典型免疫抑制ITBA患者住院死亡率29.0%；死亡者氣道侵犯分數較高（中位數3比2分，p=0.007），pseudomembranous phenotype比例差異未達顯著。
不嘻嘻：沒有典型免疫低下也中招，Aspergillus 真是不挑客群。
Psoriasis: Which therapy for which patient, updated, part II. Focus on special populations and chronic infections¶
Authors: Karpoff K et al. | Journal: J Am Acad Dermatol | Date: 2026 Oct 22
DOI: 10.1016/j.jaad.2026.10.033 | PMID: 42913858
TL;DR: 此綜述整理中重度psoriasis於妊娠、兒童、慢性感染及難治表型的systemic therapy選擇；IL-17、IL-23、IL-36、TNF-α、TYK2與JAK等標靶治療選項增加，但部分情境仍缺乏比較資料。
不嘻嘻：選項愈來愈多，真正能安心選的比較資料還在路上。
Outcomes of patients diagnosed with de novo malignancies after lung transplantation¶
Authors: Yuasa I et al. | Journal: Respir Investig | Date: 2026 Oct 22
DOI: 10.1016/j.resinv.2026.101532 | PMID: 42913272
TL;DR: 413名肺移植者中53名（12.8%）發生de novo malignancy；PTLD中位發生於8個月，solid tumor為64個月，10年累積發生率16.8%。接受curative treatment者診斷後2年存活率87.9%，高於非curative組16.7%。
嘻嘻：及早根治惡性腫瘤，肺移植後也還能留住好預後。
Association of PCR cycle threshold values in respiratory specimens with mechanical ventilation and mortality in HIV-negative pneumocystis jirovecii pneumonia¶
Authors: Lv W et al. | Journal: J Infect Public Health | Date: 2026 Oct 17
DOI: 10.1016/j.jiph.2026.103391 | PMID: 42913058
TL;DR: 184名HIV-negative PJP患者中37%需MV、38%死亡；較高Ct與較低MV風險相關（aOR 0.755），亦與較低PJP死亡風險相關（aHR 0.842），但結果仍待驗證。
嘻嘻：Ct或許能幫忙分流，臨床判斷終於多一盞小燈。
Benefits and risks of induction immunosuppression in pediatric autoimmune liver disease from SPLIT Registry¶
Authors: Jarasvaraparn C et al. | Journal: Liver Transpl | Date: 2026 Oct 23
DOI: 10.1097/LVT.0000000000001030 | PMID: 42912646
TL;DR: SPLIT Registry 445名兒童AILD肝移植者中，IL2RA組30日biopsy-confirmed rejection為11.2%，低於corticosteroids組20.9%與ATG組28%。ATG使30–90日culture-proven infection風險增10倍（aOR 10.0），5年存活無差異。
不嘻嘻：ATG防排斥很用力，感染風險也跟著開十倍加成。
Health, workforce, and cost trade-offs of HIV programme prioritization strategies in Malawi¶
Authors: Mangal TD et al. | Journal: AIDS | Date: 2026 Oct 23
DOI: 10.1097/QAD.0000000000004643 | PMID: 42912563
TL;DR: 馬拉威模型推估，HIV testing減半至2050年將增加55,200例HIV/AIDS死亡及328萬DALYs，但節省5.389億美元；合併削減testing、monitoring與prevention雖省8.12億美元，仍增加80,960例AIDS死亡。
不嘻嘻：省下預算的代價是更多死亡，這筆帳實在笑不出來。
Safety of tuberculosis-preventive treatment in children aged under 5 years: A rapid review¶
Authors: Uchimura LYT et al. | Journal: Rev Soc Bras Med Trop | Date: 2026
DOI: 10.1590/0037-8682-0029-2026 | PMID: 42912081
TL;DR: 納入5項研究的rapid review顯示，5歲以下兒童接受isoniazid-based TPT之不良事件多為可逆的輕微肝酵素上升或周邊神經病變；嚴重hepatotoxicity罕見，主要見於HIV兒童，短療程與免疫低下者證據有限。
嘻嘻：小小孩做TPT大致安全，預防結核可以更放心往前。
Clinical Impact of Busulfan Pharmacokinetic Monitoring in Pediatric Allogeneic Transplants: Perspectives from A Transplant Center in A Low- and Middle- Income Country¶
Authors: Bhat S et al. | Journal: Pediatr Hematol Oncol | Date: 2026 Oct 22
DOI: 10.1080/08880018.2026.2750856 | PMID: 42910551
TL;DR: 236名兒童接受busulfan-based HSCT，Bu-PK monitoring組mixed chimerism較低（4.6%比24.1%；OR 0.16，95% CI 0.05–0.43），即使劑量超過標準125%亦未增加毒性或死亡。
嘻嘻：Bu-PK monitoring讓兒童移植劑量不再只能憑感覺。
Beyond infection: the longitudinal impact of genitourinary tuberculosis on urologic and reproductive health¶
Authors: Kazal FH et al. | Journal: World J Urol | Date: 2026 Oct 23
DOI: 10.1007/s00345-026-06886-0 | PMID: 42909650
TL;DR: 1,503名GUTB患者在診斷前後皆有較高泌尿科事件風險：high-grade UE HR分別為2.5與2.7，low-grade UE為2.0與1.6；診斷前不孕風險亦升高（HR 2.6），提示可能存在未辨識病程。
不嘻嘻：GUTB拖得夠久，泌尿與生育功能都得一起買單。
🟢 One Health / Zoonoses¶
Multi-omics-driven predictive modelling of antimicrobial resistance emergence in African food value chains under climate change scenarios¶
Authors: Edo GI et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120811 | PMID: 42914476
TL;DR: 奈及利亞487件食品與192件環境檢體之multi-omics模型中，XGBoost預測AMR的AUROC為0.942、sensitivity 0.91、specificity 0.89；carbapenemase genes見於8.6%檢體，升溫為ARG abundance最強預測因子。
不嘻嘻：氣溫一升，ARG也跟著長；氣候變遷連抗藥性都在助攻。
Genomic diversity, farm-level persistence, and food safety risk traits of Staphylococcus aureus in small-ruminant raw milk dairy chains in central Italy¶
Authors: Savelli D et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120793 | PMID: 42914468
TL;DR: 義大利15座小型乳羊牧場425件檢體中，S. aureus檢出率48.9%，食品檢體為62.1%；WGS顯示牧場特異cluster及跨季節持續存在，常見AMR genes為blaZ、tet(M)與tet(K)。
不嘻嘻：生乳鏈裡的S. aureus常駐不走，乳酪控先別太浪漫。
Zearalenone promotes hepatic lipid accumulation via EGFR-HSP90 complex stabilization¶
Authors: Huangfu B et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120789 | PMID: 42914464
TL;DR: Zearalenone在C57BL/6J小鼠與HepG2 cells中藉穩定EGFR-HSP90 complex，活化EGFR-SREBP1c並增加脂質生成；Artemether破壞此complex後可減輕脂質堆積，erlotinib則逆轉相關效應。
嘻嘻：黴菌毒素的代謝傷害，終於找到可下手的分子破口。
Thermal inactivation kinetics of foodborne viruses across food matrices: a Bayesian meta-analysis and predictive framework¶
Authors: Wu W et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120750 | PMID: 42914440
TL;DR: 涵蓋29項研究的Bayesian meta-analysis顯示，食物matrix是病毒熱抗性最強預測因子；貝類D60°C為4.30分鐘（95% CrI 1.86–10.79），RT-qPCR的genome signal下降則明顯慢於infectivity。
嘻嘻：熱過不等於安全，這套模型能讓加熱不再只是憑手感。
Mapping the resistome of five meat-processing facilities through long-read metagenomics¶
Authors: Fernández-Trapote E et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120747 | PMID: 42914438
TL;DR: long-read metagenomics顯示肉品加工線ARG abundance自屠宰場至分切廠逐步下降；Acinetobacter、Aeromonas與Psychrobacter為主要ARG carriers，drains為重要reservoir，並檢出逾100條攜帶多重ARG的plasmid contigs或long reads。
不嘻嘻：排水孔又成ARG避風港，清潔死角果然最會藏故事。
Escherichia coli O157:H7 sublethally injured by freezing stress: Physiological characteristics and mechanisms underlying its formation and resuscitation¶
Authors: Niu L et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120741 | PMID: 42914434
TL;DR: 冷凍21小時後，Escherichia coli O157:H7 sublethally injured cells比例逾80%；於25°C復甦8小時伴隨代謝與膜重塑。1/2×MIC oregano essential oil使受損比例由79.73%降至22.70%，支持膜標靶hurdle strategy。
不嘻嘻：冷凍沒殺乾淨，E. coli 還能回魂，廚房的戲真多。
A quantitative risk assessment of Bacillus cereus in tofu treated with carbon quantum dots derived from tangerine peels¶
Authors: Kim YH et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120705 | PMID: 42914421
TL;DR: 以柑橘皮製備的CQDs處理包裝豆腐後，B. cereus 腹瀉風險由對照組2.58×10⁻⁵（19/10萬例）降至0；CQD組風險未受外在因素影響。
嘻嘻：橘皮副產物也能幫豆腐把風險歸零，食安界的柑橘奇兵。
Predictive modeling of the growth of Listeria monocytogenes in meat matrices containing sophorolipids produced by Starmerella bombicola¶
Authors: da Silva NG et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120701 | PMID: 42914419
TL;DR: sophorolipids在肉品基質抑制 L. monocytogenes 生長：牛肉湯0.12 mg/mL使最大生長速率約降50%，生豬肉香腸20 mg/g呈bacteriostatic effect。
嘻嘻：肉品防線多了一位微生物製造的幫手，值得繼續追蹤實場表現。
A multi-method framework for antimicrobial resistance hazard ranking: Application to the poultry processing chain¶
Authors: Papić B et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120687 | PMID: 42914412
TL;DR: 肉雞加工線頸皮的主要ARG豐度與菌數隨加工顯著下降，但降幅受雞群及屠宰場影響；以WGS與shotgun sequencing建立的半定量AMR hazard ranking可區辨不同風險樣本。
嘻嘻：能把AMR風險分層，才知道加工線該先盯哪一段。
Mixed-species slaughterhouses represent potential ecological hotspots associated with IS1-driven plasmid evolution and dissemination of tet(X4)¶
Authors: Huang Y et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120548 | PMID: 42914392
TL;DR: 混合物種屠宰場來源DAR-EC600的tet(X4) plasmid 14日保留率逾95%，且conjugation efficiency較單一物種設施株高；IS1 hotspot可能促進resistance與virulence共選擇。
不嘻嘻：屠宰場像 plasmid 聯誼會，還替 tet(X4) 安排了長住套房。
Phenotypic and genomic characterization of Salmonella isolates from pre-cooked seasoned chicken: predominant serovars and associations between mobile genetic element and antimicrobial resistance dissemination¶
Authors: Xu B et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120589 | PMID: 42914322
TL;DR: 中國424份預熟調味雞肉中17.69%檢出 Salmonella，149株中45.64%為MDR；S. Kentucky與S. Indiana皆為MDR，且2株S. Kentucky與人類臨床株僅差18及19個cgSNP。
不嘻嘻：預熟雞肉端出一桌MDR，離臨床株還近得令人食慾下降。
Co-evolution of the pangenome, mobile genetic elements, and antimicrobial resistance genes reveals the public health risks of the dominant Salmonella 4,[5],12:i:- ST34 clone¶
Authors: Chen J et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120546 | PMID: 42914301
TL;DR: 全球4,747株 Salmonella 4,[5],12:i:-基因組顯示ST34族群約於2016年達峰，50個ARG隨時間增加；人與豬來源株的可變ARG與pangenome基因共享度最高，Jaccard分別為0.65及0.77。
不嘻嘻：豬與人共享的不只餐桌，連ARG家底也愈來愈像。
Adaptive evolution of fluoroquinolone resistance in foodborne Salmonella: From metabolic suppression to multidimensional defense mechanisms¶
Authors: Li J et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120850 | PMID: 42914275
TL;DR: Salmonella Typhimurium經5種fluoroquinolone暴露後3–10日取得抗藥性；gatifloxacin誘發最快且最高cross-resistance，biofilm formation是抗藥性最強貢獻因子。
不嘻嘻：Salmonella 學抗藥性比我們學新指南快，biofilm 還來加課。
Prevalence, antimicrobial resistance, and genomic characteristics of fish-derived Aeromonas veronii in the freshwater food chain in Xinjiang, China¶
Authors: Qi J et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120775 | PMID: 42914232
TL;DR: 中國新疆804份養殖場與水產品市場樣本中25.87%分離到 A. veronii，88.94%為MDR；39株MDR富集定序株具32種ST與開放pangenome，未見單一dominant clone擴張。
不嘻嘻：魚貨供應鏈裡的 A. veronii 各自精彩，MDR 卻很有共識。
A stable atypical H2S-negative, non-motile Salmonella Infantis variant from a human isolate associated with a barA stop-gain mutation¶
Authors: Fesina D et al. | Journal: Microbiol Spectr | Date: 2026 Oct 22
DOI: 10.1128/spectrum.01683-26 | PMID: 42910941
TL;DR: 奧地利人類來源S. Infantis出現穩定H2S-negative、non-motile variant；其具21個特異突變，包括barA stop-gain，可能造成培養型常規監測漏檢。
不嘻嘻：連 S. Infantis 都學會隱身，傳統培養監測又得多猜一題。
資料來源：PubMed (articles retrieved 2026-10-24)