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Daily Journal Digest — 2026-11-02

過去 24 小時新增：Transplant ID × 2、One Health × 10，共 12 篇。

⭐ 今日亮點

🔬 深入評讀

The Genetic Legacy of Thermal Processing in Pasteurized Foods: Persistence of Antimicrobial Resistance Genes, Potential for Horizontal Gene Transfer, and a Proposed Genetic Legacy Index

Foodborne Pathog Dis | IF 2.5 | DOI | PMID 42969086

  • 設計：敘述性綜述，整合 pasteurization 後 extracellular DNA、membrane vesicles 與 bacteriophages 的命運及 ARG 證據；摘要未交代檢索方法、研究期間或地區。
  • 樣本：非原始人群研究，未提供納入研究數、受試者數或追蹤期；討論對象為 pasteurized milk 與 heat-treated meat 中熱滅活菌衍生物。
  • 關鍵論點：作者區分 target sequence 偵測、結構完整性與真實情境下 transfer 的證據層級。ARG sequences 在 pasteurization 後持續存在已有紀錄，但 foodborne dead-cell material 在體內造成 functional ARG transfer 尚無直接證據；GLI 結合 extracellular DNA abundance、ARG load 與 ARG-mobile genetic element linkage，僅是待驗證的研究與 surveillance 架構，非產品放行標準。
  • Limitation：系統性檢索、納入標準與偏倚評估是否進行，摘要未交代；核心暴露途徑缺乏 in vivo functional-transfer 證據，且 GLI 未經驗證，不能據以推定人體風險或設定監管門檻。
  • Bottom line：可把 GLI 視為 One Health 研究假說與 surveillance 設計方向，但目前不應將 pasteurized food 中 ARG 訊號等同可轉移的臨床 AMR 風險。

🔴 Transplant & Opportunistic Infections

Factors Associated With Candidemia in Hospitalised Patients in Mumbai, India: A Single Centre Retrospective Observational Study

Authors: Shivaprakash S et al. | Journal: Cureus | Date: 2026 Oct
DOI: 10.7759/cureus.117338 | PMID: 42968780

TL;DR: 孟買單中心139例 candidemia較259名對照，使用inotropes、隔離及total parenteral nutrition逾5日相關（aOR 2.51、2.11、3.70）；死亡HR 1.43未達顯著。

不嘻嘻：candidemia的危險因子還是那幾位老面孔。

Posttransplant lymphoproliferative disorders following hematopoietic stem cell transplantation: a clinicopathological study of a large single-center cohort

Authors: Lin J et al. | Journal: Ann Hematol | Date: 2026 Aug 05
DOI: 10.1007/s00277-026-07225-4 | PMID: 42967967

TL;DR: 37例HSCT後PTLD發生率為2.4%，中位發病時間3個月，81.1%於6個月內發生；死亡率27%，主要死於PTLD治療後感染，診斷後中位存活3.5個月。

不嘻嘻：PTLD剛確診，感染就來補最後一刀。

🟢 One Health / Zoonoses

Assessment of Listeria monocytogenes cross-contamination from enoki mushrooms to ready-to-eat foods in commercial hot pot settings

Authors: Qu Y et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120991 | PMID: 42967761

TL;DR: 火鍋食用期 Listeria monocytogenes 自金針菇至木筷轉移率78.11%，再至酥肉67.99%；經木筷污染酥肉的暴露量0.030 log CFU/g，高於儲存期萵苣的0.001 log CFU/g。

不嘻嘻：火鍋筷子原來也兼職病原接駁車。

Mg2+ deficiency affects heat shock resistance in Escherichia coli

Authors: Vaneynde D et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120975 | PMID: 42967754

TL;DR: 反覆熱循環使生長期 Escherichia coli MG1655獲得heat shock resistance，多數演化株帶有mgrB loss-of-function mutation；PhoPQ依賴性MgtA Mg2+ importer上調為關鍵機制。

不嘻嘻：E. coli連烤箱歷練都能練成抗性。

Residual disinfectants in food-processing environments promote RP4 plasmid-mediated conjugative transfer through distinct donor and recipient responses

Authors: Duan Y et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120879 | PMID: 42967705

TL;DR: NaClO與BZK均以濃度及時間依賴方式增加RP4 plasmid conjugative transfer；NaClO主要驅動donor oxidative stress，BZK則快速活化recipient SOS response並促進細胞互動。

不嘻嘻：消毒劑殘留竟成質體牽線的媒人。

Biocontrol potential of bacteriophage CAU_YEP3 against Yersinia enterocolitica O3 in food-contact surfaces and refrigerated food systems

Authors: Lee HR et al. | Journal: Food Res Int | Date: 2026 Dec 01
DOI: 10.1016/j.foodres.2026.120780 | PMID: 42967686

TL;DR: bacteriophage CAU_YEP3使食物接觸表面 Yersinia enterocolitica O3減少1.29–2.84 log10 CFU/cm2；豬肉4°C、MOI 1–100可減少1.60–1.93 log10 CFU/g。

嘻嘻：bacteriophage守住冷藏豬肉，頗有上場價值。

Prevalence, antimicrobial resistance, and molecular resistance determinants of non-typhoidal Salmonella in Nigeria: a systematic review and meta-analysis with a one health perspective

Authors: Akinbobola JS et al. | Journal: BMC Infect Dis | Date: 2026 Aug 03
DOI: 10.1186/s12879-026-14168-8 | PMID: 42968069

TL;DR: 奈及利亞49項研究共54,415件檢體，non-typhoidal Salmonella 合併檢出率7.2%；ciprofloxacin抗藥率45.6%、tetracycline為73.3%，carbapenems於現有資料未見抗藥。

不嘻嘻：ciprofloxacin快退場，細菌倒是很會續約。

Rapid RPA-Cas12a Assay for Streptococcus agalactiae Serotype III in Fish Featuring Photocontrolled One-Pot Detection

Authors: Chaijarasphong T et al. | Journal: J Fish Dis | Date: 2026 Nov 01
DOI: 10.1111/jfd.70320 | PMID: 42968190

TL;DR: 針對魚類 Streptococcus agalactiae serotype III的RPA-Cas12a檢測，LoD為100 copies/reaction，37°C可於1小時完成；photocontrolled one-pot format與two-step assay及PCR皆100%一致。

嘻嘻：一小時辨認魚病原，現場檢測很有戲。

Large-Scale Genomic Surveillance of Swine Influenza A Viruses in Europe Highlights Increased Reassortment Potential and Field-Based Associations With Clinical Manifestations

Authors: Lillie-Jaschniski K et al. | Journal: Transbound Emerg Dis | Date: 2026
DOI: 10.1155/tbed/7198173 | PMID: 42968597

TL;DR: 2022–2023年歐洲16國134個豬場中，93%檢出swIAV；定序辨識23種genotype，其中12種未曾報告，顯示病毒持續reassortment及高度遺傳多樣性。

不嘻嘻：豬流感持續洗牌，人畜界線又更模糊了。

The Genetic Legacy of Thermal Processing in Pasteurized Foods: Persistence of Antimicrobial Resistance Genes, Potential for Horizontal Gene Transfer, and a Proposed Genetic Legacy Index

Authors: Song S et al. | Journal: Foodborne Pathog Dis | Date: 2026 Nov 02
DOI: 10.1177/15353141261502605 | PMID: 42969086

TL;DR: 敘述性回顧指出pasteurization後ARG sequence可持續存在，但尚無foodborne dead-cell material於體內進行functional transfer的證據；提出未經驗證的Genetic Legacy Index作為研究與surveillance框架。

不嘻嘻：指數先提出了，證據還在路上趕車。

Household Cluster of Salmonella Infection Associated with a Pet Bearded Dragon in Japan: cgMLST-Based Source Attribution and Gaps in Recognition

Authors: Matsuoka R et al. | Journal: Jpn J Infect Dis | Date: 2026 Oct 30
DOI: 10.7883/yoken.JJID.2026.134 | PMID: 42968271

TL;DR: 日本同戶兩名手足與鬃獅蜥的初始 Salmonella isolates經cgMLST無差異，支持reptile-associated household cluster；哥哥追蹤菌株不同，提示爬蟲類可攜帶多株菌並造成反覆暴露。

不嘻嘻：鬃獅蜥可愛歸可愛，送菌也不手軟。

Molecular Epidemiology and Spatial Distribution of Toxocara canis and Toxocara cati in Avian Paratenic Hosts: A One Health Perspective From Northeastern Iran

Authors: Rezaiemanesh MR et al. | Journal: Vet Med Sci | Date: 2026 Nov
DOI: 10.1002/vms3.71310 | PMID: 42967604

TL;DR: 伊朗東北部100隻鳥、300份組織中，Toxocara spp. DNA於35.0%鳥類及17.0%組織檢出，以 Toxocara canis 68.6%最多；麻雀、眼及肝組織陽性率較高。

不嘻嘻：麻雀與寄生蟲的 One Health 默契太好了。

資料來源：PubMed (articles retrieved 2026-11-02)